Laxman Yetukuri
University of Helsinki
44 Papers
247 Citations
Laxman Yetukuri is an academic researcher from University of Helsinki. The author has contributed to research in topics: Adipose tissue & Lipid metabolism. The author has an hindex of 27, co-authored 38 publications. Previous affiliations of Laxman Yetukuri include VTT Technical Research Centre of Finland & Åbo Akademi University.
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Papers
The gut microbiota modulates host energy and lipid metabolism in mice.
Vidya Velagapudi,Rahil Hezaveh,Christopher S. Reigstad,Peddinti Gopalacharyulu,Laxman Yetukuri,Sama Islam,Jenny Felin,Rosie Perkins,Jan Borén,Matej Orešič,Matej Orešič,Fredrik Bäckhed +11 more
TL;DR: It is shown that the gut microbiota affects both host energy and lipid metabolism and highlights its role in the development of metabolic diseases.
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Novel Theranostic Opportunities Offered by Characterization of Altered Membrane Lipid Metabolism in Breast Cancer Progression
Mika Hilvo,Carsten Denkert,Laura Lehtinen,Berit Maria Müller,Scarlet F. Brockmöller,Tuulikki Seppänen-Laakso,Jan Budczies,Elmar Bucher,Laxman Yetukuri,Sandra Castillo,Emilia Berg,Heli Nygren,Marko Sysi-Aho,Julian L. Griffin,Oliver Fiehn,Sibylle Loibl,Christiane Richter-Ehrenstein,Cornelia Radke,Tuulia Hyötyläinen,Olli Kallioniemi,Kristiina Iljin,Matej Orešič +21 more
TL;DR: Analyzing the global lipid profiles of breast cancer, integrating the results to protein expression, and validate the findings by functional experiments imply that phospholipids may have diagnostic potential as well as that modulation of their metabolism may provide therapeutic opportunities in breast cancer treatment.
529
Dysregulation of lipid and amino acid metabolism precedes islet autoimmunity in children who later progress to type 1 diabetes.
Matej Orešič,Satu Simell,Marko Sysi-Aho,Kirsti Näntö-Salonen,Tuulikki Seppänen-Laakso,Vilhelmiina Parikka,Mikko Katajamaa,Anne Hekkala,Ismo Mattila,Päivi Keskinen,Laxman Yetukuri,Arja Reinikainen,Jyrki Lähde,Tapani Suortti,Jari Hakalax,Tuula Simell,Heikki Hyöty,Riitta Veijola,Jorma Ilonen,Jorma Ilonen,Riitta Lahesmaa,Mikael Knip,Olli Simell +22 more
TL;DR: Serum metabolite profiles were compared between sample series drawn from children who progressed to type 1 diabetes and controls who remained nondiabetic and permanently autoantibody negative, finding that autoimmunity may be a relatively late response to the early metabolic disturbances.
472
PPAR gamma 2 Prevents Lipotoxicity by Controlling Adipose Tissue Expandability and Peripheral Lipid Metabolism
Gema Medina-Gomez,Sarah L. Gray,Laxman Yetukuri,Kenju Shimomura,Sam Virtue,Mark Campbell,R. Keira Curtis,Mercedes Jimenez-Linan,Margaret Blount,Giles S.H. Yeo,Miguel Ángel López,Tuulikki Seppänen-Laakso,Frances M. Ashcroft,Matej Orešič,Antonio Vidal-Puig +14 more
TL;DR: The results indicate that the PPARg2 isoform plays an important role, mediating adipose tissue expansion in response to positive energy balance, and may be required for the β-cell hypertrophic adaptive response to insulin resistance.
Normalization method for metabolomics data using optimal selection of multiple internal standards
TL;DR: The NOMIS method proved superior in its ability to reduce the effect of systematic error across the full spectrum of metabolite peaks and can be used in analytical development of metabolomics methods by helping to select best combinations of standard compounds for a particular biological matrix and analytical platform.
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