Lawrence T. Goodnough
Stanford University
417 Papers
5K Citations
Lawrence T. Goodnough is an academic researcher from Stanford University. The author has contributed to research in topics: Blood transfusion & Medicine. The author has an hindex of 85, co-authored 417 publications. Previous affiliations of Lawrence T. Goodnough include American Red Cross & Washington University in St. Louis.
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Papers
Use of point-of-care testing for plasma therapy.
TL;DR: Clinical evidence for the effectiveness of point‐of‐care testing is summarized, along with some future directions for this strategy, for cost‐effective, targeted blood component transfusion support.
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Randomized evaluation of efficacy and safety of ferric carboxymaltose in patients with iron deficiency anaemia and impaired renal function (REPAIR-IDA): rationale and study design.
Lynda A. Szczech,Lynda A. Szczech,David B. Bregman,David B. Bregman,Robert A. Harrington,Robert A. Harrington,David Morris,Angelia Butcher,Todd A. Koch,Lawrence T. Goodnough,Myles Wolf,Jane E. Onken +11 more
TL;DR: Ferric carboxymaltose (FCM) is a novel IV iron formulation designed to permit larger infusions compared to currently available IV standards such as Venofer(R) (iron sucrose) in patients with IDA and NDD-CKD at increased risk for cardiovascular disease.
•Journal Article
Infusion pump-mediated mechanical hemolysis in pediatric patients.
Jonathan Hughes,Janet McNaughton,Jennifer Andrews,Tracy I. George,Cassandra Bergero,Kimberly A. Pyke-Grimm,Susan A. Galel,Christopher L. Gonzalez,Lawrence T. Goodnough,Magali J. Fontaine +9 more
TL;DR: The investigation determined that infusion of higher hematocrit units using a specific commercial pump was associated with mechanical hemolysis and the change to units with lower hematOCrit through an alternative pump has been an effective corrective action to date.
14
Transfusion medicine : support of patients undergoing cardiac surgery.
TL;DR: Aprotinin has been shown to preserve hemostasis and reduce allogeneic blood exposure to a greater extent than the antifibrinolytic agents tranexamic acid and aminocaproic acid and need further evaluation in patients undergoing cardiac surgery.
14
Bovine aortic endothelial cells elaborate an inhibitor of the generation of lipopolysaccharide-stimulated human blood monocyte procoagulant activity.
Lawrence T. Goodnough,Mary Ellen Kleinhenz,George H. Goldsmith,Nicholas P. Ziats,A L Robertson +4 more
TL;DR: Investigation of bovine aortic endothelial cell culture supernatants demonstrated that endothelial cells elaborate a potent inhibitor of monocyte procoagulant activity, and further studies on subpopulations of mononuclear cells demonstrated that permeability of endothelial inhibitor selectively decreased the generation of monocytes pro coagULant activity and interfered with T lymphocyte amplification ofmonocyte production of procoagenic activity.