Lautaro Taborga

TL;DR: The results suggest that the new derivatives of geranylphenols have the ability to block the mycelial development of the plant pathogen B. cinerea and that this capacity depends strongly on the structural features and lipophilicity of the compounds.

TL;DR: The known geranylhydroquinone 2, geranylorcinol 4 and the derivative (E)-4-(3,7-dimethyl octa-2,6-dienyl)-5-methylbenzene-1,3,5-triol (geranylphloroglucinol) were prepared by Electrophilic Aromatic Substitution (EAS) reactions between the corresponding phenol derivatives containing electron-donor subtituents and geraniol using BF 3 ×OEt 2 as a catalyst.

TL;DR: It was found that compounds 12 and 13, induced changes in mitochondrial membrane permeability in those cancer cell lines, and such induction was associated with the depletion of mitochondrial membrane potential.

TL;DR: The inhibitory effects on the mycelial growth of plant pathogen Botritys cinerea have been evaluated for a series of geranylphenols substituted with one, two and three methoxy groups in the aromatic ring and the results show that the antifungal activity depends on the structure of the geranyl phenols.