Laury Baillon
Imperial College London
17 Papers
15 Citations
Laury Baillon is an academic researcher from Imperial College London. The author has contributed to research in topics: Virus & Biology. The author has an hindex of 5, co-authored 8 publications.
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Papers
The furin cleavage site in the SARS-CoV-2 spike protein is required for transmission in ferrets.
Thomas P. Peacock,Daniel H. Goldhill,Jie Zhou,Laury Baillon,Rebecca Frise,Olivia C. Swann,Ruthiran Kugathasan,Rebecca Penn,Jonathan Brown,Raul Y. Sanchez-David,Luca Braga,Maia Kavanagh Williamson,Jack A. Hassard,Ecco Staller,Brian Hanley,Michael Osborn,Mauro Giacca,Andrew D. Davidson,David A. Matthews,Wendy S. Barclay +19 more
TL;DR: In this article, the authors show that the polybasic insertion of SARS-CoV-2 has a poly-basic insertion (PRRAR) at the S1/S2 cleavage site that can be cleaved by furin.
Histopathological findings and viral tropism in UK patients with severe fatal COVID-19: a post-mortem study.
Brian Hanley,Kikkeri N. Naresh,Candice Roufosse,Andrew G. Nicholson,Justin Weir,Graham S Cooke,Mark Thursz,Pinelopi Manousou,Richard Corbett,Robert D. Goldin,Safa Al-Sarraj,Alireza Abdolrasouli,Olivia C. Swann,Laury Baillon,Rebecca Penn,Wendy S. Barclay,Patrizia Viola,Michael Osborn,Michael Osborn +18 more
- 20 Aug 2020
TL;DR: This series supports clinical data showing that the four dominant interrelated pathological processes in severe COVID-19 are diffuse alveolar damage, thrombosis, haemophagocytosis, and immune cell depletion.
The furin cleavage site of SARS-CoV-2 spike protein is a key determinant for transmission due to enhanced replication in airway cells
Thomas P. Peacock,Daniel H. Goldhill,Jie Zhou,Laury Baillon,Rebecca Frise,Olivia C. Swann,Ruthiran Kugathasan,Rebecca Penn,Jonathan C Brown,Raul Y. Sanchez-David,Maia Kavanagh Williamson,Jack A. Hassard,Ecco Staller,Brian Hanley,Michael Osborn,Andrew D. Davidson,Wendy S. Barclay +16 more
TL;DR: It is found that the polybasic insertion is selected for in lung cells and primary human airway epithelial cultures but selected against in Vero E6, a cell line used for passaging SARS-CoV-2, and depends on expression of the cell surface protease that allows virus entry independent of endosomes thus avoiding antiviral IFITM proteins.
Increased transmission of SARS-CoV-2 lineage B.1.1.7 (VOC 2020212/01) is not accounted for by a replicative advantage in primary airway cells or antibody escape
Jonathan C Brown,Daniel H. Goldhill,Jie Zhou,Thomas P. Peacock,Rebecca Frise,Niluka Goonawardane,Laury Baillon,Ruthiran Kugathasan,Andreia Lucia Pinto,Paul F. McKay,Jack A. Hassard,Maya Moshe,Aran Singanayagam,Thomas Burgoyne,Wendy S. Barclay +14 more
TL;DR: In this article, the authors demonstrate that there is no difference in viral replication between B.1.7 and other contemporaneous SARS-CoV-2 strains in primary human airway epithelial (HAE) cells.
Resistance of endothelial cells to SARS-CoV-2 infection in vitro
Blerina Ahmetaj-Shala,Thomas P. Peacock,Laury Baillon,Olivia C. Swann,Hime Gashaw,Wendy S. Barclay,Jason Mitchell +6 more
TL;DR: Endothelial cells are resistant to infection with SARS-CoV-2 virus, in line with relatively low levels of ACE2 and TMPRSS2, suggesting that the vascular dysfunction and thrombosis seen in severe COVID-19 is a result of factors released by adjacent infected cells and/or circulating, systemic inflammatory mediators.