Laurie Phillips
University of Toronto
4 Papers
288 Citations
Laurie Phillips is an academic researcher from University of Toronto. The author has contributed to research in topics: Gene & Antigen. The author has an hindex of 4, co-authored 4 publications.
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Papers
Rearrangement and transcription of the β-chain genes of the T-cell antigen receptor in different types of murine lymphocytes
Mitchell Kronenberg,Joan Goverman,Regina Haars,Marie Malissen,Ellen Kraig,Laurie Phillips,Terry L. Delovitch,Nicole Suciu-Foca,Leroy Hood +8 more
TL;DR: Four of five suppressor T-cell hybridomas examined have deleted all known joining (Jβ) gene segments and Cβ genes and therefore may have antigen receptors encoded by different T- cell receptor gene families.
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Monoclonal antibodies to the Ca2+ + Mg2+-dependent ATPase of sarcoplasmic reticulum identify polymorphic forms of the enzyme and indicate the presence in the enzyme of a classical high-affinity Ca2+ binding site.
Elizabeth E. Zubrzycka-Gaarn,Glen M. MacDonald,Laurie Phillips,A. O. Jorgensen,David H. MacLennan +4 more
TL;DR: The cross-reactivity of five monoclonal antibodies prepared against the purified Ca2+ + Mg2+-dependent ATPase of rabbit skeletal muscle sarcoplasmic reticulum was found to cross-react with calsequestrin and with a series of other Ca2-binding proteins and their proteolytic fragments, suggesting that it has specificity for antigenic determinants that make up the Ca2+.
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•Journal Article
Amino acid residues in the T cell receptor CDR3 determine the antigenic reactivity patterns of insulin-reactive hybridomas.
TL;DR: Examination of TCR gene usage in a panel of beef insulin/I-Ad-restricted T cell hybrids obtained from BALB/c mice demonstrated the critical role for CDR3 in determining antigenic reactivity in beef insulin-reactive hybrids and are compatible with the current model of T CR/peptide/MHC interaction.
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Both MHC and background gene heterozygosity alter T cell receptor repertoire selection in an antigen-specific response
Brian Vukusic,Lorraine Poplonski,Laurie Phillips,Judy Pawling,Terry L. Delovitch,Nobumichi Hozumi,Joan E. Wither +6 more
TL;DR: It is demonstrated that both MHC and background gene heterozygosity affect TCR repertoire selection, suggesting that the variable expression of autoimmune disease in individuals with a susceptible MHC allele may result, in part, from variability in the TCR repertoires introduced by this heter chromosome.
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