admission. This proportion could already be greater in some parts of the country and may increase if referrals of cases of self-poisoning increase faster than the facilities for their assessment and management. The provision of social work and psychiatric expertise in casualty departments may be one means of preventing unnecessary medical admissions without risk to the patients. Dr Blake's and Dr Bramble's figures do not demonstrate, however, that any advantage would attach to medical teams taking over assessment from psychiatrists except that, by implication, assessments would be completed sooner by staff working on the ward full time. What the figures actually suggest is that if assessment of overdoses were left to house doctors there would be an increase in admissions to psychiatric units (by 19°U), outpatients (by 5O°'), and referrals to social services (by 140o). So for house doctors to assess overdoses would provide no economy for the psychiatric or social services. The study does not tell us what the consequences would have been for the six patients who the psychiatrists would have admitted but to whom the house doctors would have offered outpatient appointments. E J SALTER

Vitamin D deficiency.

Preamble and Transition to ACC/AHA Guidelines to

The goals of the American College of Cardiology (ACC) and the American Heart Association (AHA) are to prevent cardiovascular diseases (CVDs); improve the management …

/pdf/2013-aha-acc-guideline-on-lifestyle-management-to-reduce-4cwv0mif24.pdf

2013 AHA/ACC Guideline on Lifestyle Management to Reduce Cardiovascular Risk

Practice Guideline2013 AHA/ACC Guideline on Lifestyle Management to Reduce Cardiovascular Risk: A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines☆

The purpose of this review was to estimate the extent of under-reporting of adverse drug reactions (ADRs) to spontaneous reporting systems and to investigate whether there are differences between different types of ADRs. A systematic literature search was carried out to identify studies providing a numerical estimate of under-reporting. Studies were included regardless of the methodology used or the setting, e.g. hospital versus general practice. Estimates of under-reporting were either extracted directly from the published study or calculated from the study data. These were expressed as the percentage of ADRs detected from intensive data collection that were not reported to the relevant local, regional or national spontaneous reporting systems. The median under-reporting rate was calculated across all studies and within subcategories of studies using different methods or settings. In total, 37 studies using a wide variety of surveillance methods were identified from 12 countries. These generated 43 numerical estimates of under-reporting. The median under-reporting rate across the 37 studies was 94% (interquartile range 82-98%). There was no significant difference in the median under-reporting rates calculated for general practice and hospital-based studies. Five of the ten general practice studies provided evidence of a higher median under-reporting rate for all ADRs compared with more serious or severe ADRs (95% and 80%, respectively). In comparison, for five of the eight hospital-based studies the median under-reporting rate for more serious or severe ADRs remained high (95%). The median under-reporting rate was lower for 19 studies investigating specific serious/severe ADR-drug combinations but was still high at 85%. This systematic review provides evidence of significant and widespread under-reporting of ADRs to spontaneous reporting systems including serious or severe ADRs. Further work is required to assess the impact of under-reporting on public health decisions and the effects of initiatives to improve reporting such as internet reporting, pharmacist/nurse reporting and direct patient reporting as well as improved education and training of healthcare professionals.

Under-reporting of adverse drug reactions : a systematic review.

Guidelines for the Diagnosis and Management of Gastroesophageal Reflux Disease

Angiœdème généralisé avec syndrome de fuite capillaire sous piroxicam : une observation

Prevalence of Cardiovascular Risk Factors and Incidence of Venous and Arterial Thrombosis in Non-Splenectomized Immune Thrombocytopenia Adult Patients in Sweden and France. Results from Two Nationwide Studies

L’exposition aux vaccins recommandés est faible chez les patients non splénectomisés atteints de thrombopénie immunologique primaire et exposés au rituximab. Résultats de l’étude FAITH (French Adult Immune Thrombocytopenia: a pHarmacoepidemiological study)

Resume Introduction Le syndrome TAFRO est un syndrome inflammatoire systemique proche de la maladie de Castleman, associant, anasarque, fievre, insuffisance renale et/ou fibrose reticulinique et organomegalie. Nous rapportons la premiere observation de vascularite necrosante compliquant un syndrome TAFRO. Observation Une femme de 69 ans presentait amaigrissement, fievre, anasarque, splenomegalie, adenomegalies, oligoanurie et livedo necrotique extensif au decours d’une diarrhee aigue. Les examens biologiques montraient une anemie, une thrombopenie, une insuffisance renale, une hypergammaglobulinemie, un clone lymphocytaire B circulant minime, une hypoparathyroidie et une hypothyroidie auto-immune. La biopsie cutanee montrait une vascularite avec necrose fibrinoide des petits vaisseaux. Le tocilizumab, associe a des perfusions de methylprednisolone, etait inefficace. Les echanges plasmatiques associes au rituximab ont permis la remission initiale, consolidee par 6 cures de rituximab, cyclophosphamide et dexamethasone. Conclusion Le syndrome TAFRO peut s’associer a une vascularite necrosante cutanee. La resistance possible au tocilizumab merite d’etre connue.

TAFRO syndrome and cutaneous necrotizing vasculitis

Risk of Vaccine-Induced Immune Thrombocytopenia in Children. Nationwide Case Cross-over and Self-Controlled Case Series Studies in France

Handle everyday research tasks with reliable, citation-backed results

Your personal Research Agent to handle research tasks with citation-backed results

Popular Tasks used by Researchers

How can I help with your research?

Meet SciSpace

Get more enhanced response by uploading the PDFs you want me to reference.

No relevant PDFs in your library

SciSpace is the AI research assistant for academics. Run systematic literature reviews on 280M+ papers, and write papers with cited sources. Trusted by 1M+ students, PhDs & researchers.

SciSpace | AI for Research

Analyze PDFs

Code & Manuscripts

Funding & Grants

Literature & Patents

Medical & Clinical Data

Systematic Review

Visualize & Present

Web & Data

Build a Google Scholar-like website for your research.

Build a website

Create charts and images for your research

Create a Chart

Write a paper for submission to a journal

Draft a manuscript

Patent Search

Design eye-catching scientific posters in minutes.

Scientific Poster Generation

Systematic Literature Review

One task is running at the moment. Your messages will be shown right after.

Drag and drop or click here to browse

Loved by <highlight>1 million+</highlight> researchers

Extract a list of specific topics and their sources from unstructured text

Topics

Compare and analyze relevant papers that matches with your search

Papers

Get insights from PDFs and bookmarked papers from your library

My library

Recent searches

Try searching for:

Catch AI-generated content in scholarly and non-scholarly content

{ai} Detector

Ai Writer

Get PDF Summaries, highlighted text explanations 

Chat with PDF

Effortlessly create in-text citations and bibliographies in APA and 2,500 other formats

Citation generator

Get explanations, summaries, and answers on academic papers

Ease up your research workflow with {scispace}'s cohort of exciting AI tools

Elevate your academic writing skills and convey your ideas the way you want

Paraphraser

Explore our range of reading and writing tools

Your file is being prepared and should be ready in a few minutes. If it's a large file, it might take a bit longer. You can close this window, and we'll email you the file when it's done.

You have reached a maximum limit of <strong>{limit}</strong> columns in the table. Remove at least <strong>1</strong> column to add or create another one.

Laurent Sailler

Author Tools

Chat about Author