Laurent Gapin
Anschutz Medical Campus
108 Papers
954 Citations
Laurent Gapin is an academic researcher from Anschutz Medical Campus. The author has contributed to research in topics: Natural killer T cell & T-cell receptor. The author has an hindex of 44, co-authored 105 publications. Previous affiliations of Laurent Gapin include La Jolla Institute for Allergy and Immunology & Pasteur Institute.
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Papers
Inflammation directs memory precursor and short-lived effector CD8(+) T cell fates via the graded expression of T-bet transcription factor.
Nikhil S. Joshi,Weiguo Cui,Anmol Chandele,Heung Kyu Lee,David Urso,James Hagman,Laurent Gapin,Susan M. Kaech +7 more
TL;DR: A mechanism by which the innate immune system sets the relative amounts of a lineage-determining transcription factor in activated CD8(+) T cells and regulates their memory cell potential is elucidated.
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Effector and memory CD8 + T cell fate coupled by T-bet and eomesodermin
Andrew M. Intlekofer,Naofumi Takemoto,E. John Wherry,E. John Wherry,Sarah A. Longworth,John T Northrup,Vikram R. Palanivel,Alan C. Mullen,Christopher R Gasink,Susan M. Kaech,Susan M. Kaech,Joseph D. Miller,Laurent Gapin,Kenneth Ryan,Andreas Russ,Tullia Lindsten,Jordan S. Orange,Ananda W. Goldrath,Ananda W. Goldrath,Rafi Ahmed,Steven L. Reiner +20 more
TL;DR: These key transcription factors T-bet and eomesodermin link the long-term renewal of memory CD8+ T cells to their characteristic effector potency, and are responsible for inducing enhanced expression of CD122, the receptor specifying interleukin 15 responsiveness.
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Tracking the response of natural killer T cells to a glycolipid antigen using CD1d tetramers.
Jennifer L. Matsuda,Jennifer L. Matsuda,Olga V. Naidenko,Laurent Gapin,Toshinori Nakayama,Masaru Taniguchi,Chyung Ru Wang,Yasuhiko Koezuka,Mitchell Kronenberg,Mitchell Kronenberg +9 more
TL;DR: It is shown that tetramers of mouse CD1d loaded with α-GalCer are a sensitive and highly specific reagent for identifying Vα14+ NK T cells and that α- GalCer–specific T lymphocytes are more widely distributed than was previously appreciated.
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The unconventional lifestyle of NKT cells
TL;DR: New studies are beginning to shed light on the development, selection, homeostasis and possible function(s) of Vα14i T cells, which are 'non-conformists' compared with the main T-cell populations, which might lead to the development of techniques for the controlled manipulation of the Vα 14i T- cell response, which could one day form the basis of immune therapies.
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T-bet Regulates the Terminal Maturation and Homeostasis of NK and Vα14i NKT Cells
Michael J. Townsend,Amy S. Weinmann,Jennifer L. Matsuda,Rachelle Salomon,Peggy J. Farnham,Christine A. Biron,Laurent Gapin,Laurie H. Glimcher +7 more
TL;DR: This work shows that mice with a targeted deletion of T-bet have a profound, stem cell-intrinsic defect in their ability to generate mature NK and Valpha14i NKT cells.
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