Laurent F. Thomas
Norwegian University of Science and Technology
48 Papers
45 Citations
Laurent F. Thomas is an academic researcher from Norwegian University of Science and Technology. The author has contributed to research in topics: Genome-wide association study & Medicine. The author has an hindex of 10, co-authored 30 publications.
Chat about Author
Papers
A genome-wide association study with 1,126,563 individuals identifies new risk loci for Alzheimer's disease.
Douglas P Wightman,Iris E. Jansen,Jeanne E. Savage,Alexey A. Shadrin,Shahram Bahrami,Shahram Bahrami,Dominic Holland,Arvid Rongve,Sigrid Børte,Sigrid Børte,Sigrid Børte,Bendik S. Winsvold,Bendik S. Winsvold,Ole Kristian Drange,Amy E Martinsen,Amy E Martinsen,Amy E Martinsen,Anne Heidi Skogholt,Cristen J. Willer,Geir Bråthen,Ingunn Bosnes,Ingunn Bosnes,Jonas B. Nielsen,Jonas B. Nielsen,Jonas B. Nielsen,Lars G. Fritsche,Laurent F. Thomas,Linda M. Pedersen,Maiken Elvestad Gabrielsen,Marianne Bakke Johnsen,Marianne Bakke Johnsen,Marianne Bakke Johnsen,Tore Wergeland Meisingset,Wei Zhou,Wei Zhou,Petroula Proitsi,Angela Hodges,Richard Dobson,Latha Velayudhan,Karl Heilbron,Adam Auton,Julia M. Sealock,Lea K. Davis,Nancy L. Pedersen,Chandra A. Reynolds,Ida K. Karlsson,Ida K. Karlsson,Sigurdur H. Magnusson,Hreinn Stefansson,Steinunn Thordardottir,Palmi V. Jonsson,Jon Snaedal,Anna Zettergren,Ingmar Skoog,Ingmar Skoog,Silke Kern,Silke Kern,Margda Waern,Margda Waern,Henrik Zetterberg,Kaj Blennow,Kaj Blennow,Eystein Stordal,Eystein Stordal,Kristian Hveem,John-Anker Zwart,John-Anker Zwart,John-Anker Zwart,Lavinia Athanasiu,Lavinia Athanasiu,Per Selnes,Ingvild Saltvedt,Sigrid Botne Sando,Ingun Ulstein,Srdjan Djurovic,Srdjan Djurovic,Tormod Fladby,Tormod Fladby,Dag Aarsland,Dag Aarsland,Geir Selbæk,Geir Selbæk,Stephan Ripke,Stephan Ripke,Stephan Ripke,Kari Stefansson,Ole A. Andreassen,Ole A. Andreassen,Danielle Posthuma,Danielle Posthuma +89 more
TL;DR: This paper identified microglia, immune cells and protein catabolism as relevant genes for late-onset Alzheimer's disease, while identifying and prioritizing previously unidentified genes of potential interest.
720
Deciphering osteoarthritis genetics across 826,690 individuals from 9 populations
Cindy G. Boer,Konstantinos Hatzikotoulas,Lorraine Southam,Lilja Stefansdottir,Yanfei Zhang,Rodrigo Coutinho de Almeida,Tian T Wu,Jie Zheng,April Hartley,Maris Teder-Laving,Anne Heidi Skogholt,Chikashi Terao,Eleni Zengini,George Alexiadis,Andrei Barysenka,Gyda Bjornsdottir,Maiken Elvestad Gabrielsen,Arthur Gilly,Thorvaldur Ingvarsson,Marianne B Johnsen,Helgi Jonsson,Margreet Kloppenburg,Almut Luetge,Sigrun H. Lund,Reedik Mägi,Massimo Mangino,Rob G H H Nelissen,Manu Shivakumar,Julia Steinberg,Hiroshi Takuwa,Laurent F. Thomas,Margo Tuerlings,Hunt All-In Pain,George C. Babis,Jason Pui Yin Cheung,Jae Hee Kang,Peter Kraft,Steven A Lietman,Dino Samartzis,P. Eline Slagboom,Kari Stefansson,Unnur Thorsteinsdottir,Jonathan H Tobias,André G. Uitterlinden,Bendik S. Winsvold,John-Anker Zwart,George Davey Smith,Pak C. Sham,Gudmar Thorleifsson,Tom R. Gaunt,Andrew P. Morris,Ana M. Valdes,Aspasia Tsezou,Kathryn S.E. Cheah,Shiro Ikegawa,Kristian Hveem,Tõnu Esko,J. Mark Wilkinson,Ingrid Meulenbelt,Ming Ta Michael Lee,Joyce B. J. van Meurs,Unnur Styrkarsdottir,Eleftheria Zeggini +62 more
TL;DR: A genome-wide association study meta-analysis across 826,690 individuals and identifies 100 independently associated risk variants across 11 osteoarthritis phenotypes, 52 of which have not been associated with the disease before.
347
Stroke genetics informs drug discovery and risk prediction across ancestries
Aniket Mishra,Rainer Malik,Tsuyoshi Hachiya,Tuuli Jürgenson,Shinichi Namba,Daniel Posner,Frederick K. Kamanu,Masaru Koido,Mingyang Shi,Yunye He,Marios K. Georgakis,Ilana Caro,Kristi Krebs,Yi-Ching Liaw,Felix Vaura,Kuang Lin,Bendik S. Winsvold,Vinodh Srinivasasainagendra,Livia Parodi,Hee-Joon Bae,Ganesh Chauhan,Michael Chong,Liisa Tomppo,Rufus Akinyemi,Gennady V. Roshchupkin,Naomi Habib,Yon Ho Jee,Jesper Qvist Thomassen,Vida Abedi,Jara Cárcel-Márquez,Marianne Nygaard,Hampton L. Leonard,Chaojie Yang,Ekaterina Yonova-Doing,Maria J. Knol,Adam J. Lewis,Renae Judy,Tetsuro Ago,Philippe Amouyel,N. Armstrong,Mark K Bakker,Traci M. Bartz,David A. Bennett,Joshua C. Bis,Constance Bordes,Sigrid Børte,Anael Cain,Paul M. Ridker,Kelly Cho,Zhengming Chen,Carlos Cruchaga,John W. Cole,Rafael de Cid,Matthias Endres,Mirjam I. Geerlings,Natalie C. Gasca,Vilmundur Gudnason,Jun Hata,Jiang He,Alicia K Heath,Yuk-Lam Ho,Aki S. Havulinna,Jemma C. Hopewell,Hyacinth I. Hyacinth,Michael Inouye,Mina A. Jacob,Christina Jeon,Christina Jern,Masahiro Kamouchi,Keith L. Keene,Takanari Kitazono,Steven J. Kittner,Takahiro Konuma,Amit Kumar,Paul Lacaze,Lenore J. Launer,Keon-Joo Lee,Kaido Lepik,Jiang Li,Liming Li,Ani Manichaikul,Hugh S. Markus,Nicholas A Marston,Thomas Meitinger,Braxton D. Mitchell,Felipe A. Montellano,Takayuki Morisaki,Thomas H. Mosley,Mike A. Nalls,Martin O'Donnell,Yukinori Okada,N. Charlotte Onland-Moret,Bruce Ovbiagele,Annette Peters,Bruce M. Psaty,Stephen S. Rich,Jonathan Rosand,Marc S. Sabatine,Ralph L. Sacco,Danish Saleheen,Else Charlotte Sandset,Veikko Salomaa,Muralidharan Sargurupremraj,Makoto Sasaki,Claudia L. Satizabal,Carsten Oliver Schmidt,Atsushi Shimizu,Nicholas L. Smith,Kelly L. Sloane,Yoichi Sutoh,Yan V. Sun,Kozo Tanno,Steffen Tiedt,Turgut Tatlisumak,Nuria P. Torres-Aguila,Hemant K. Tiwari,David-Alexandre Trégouët,Stella Trompet,Anil M. Tuladhar,Anne Tybjærg-Hansen,Riina Vibo,Shefali S. Verma,Kerri L. Wiggins,Patrik Wennberg,Daniel Woo,Peter W.F. Wilson,Huichun Xu,Qiong Yang,Kyungheon Yoon,Jin-Moo Lee,James F. Meschia,Wei Min Chen,Michèle M. Sale,Alan B. Zonderman,Michele K. Evans,James F. Wilson,Adolfo Correa,Matthew Traylor,Cathryn M. Lewis,Cara L. Carty,Jeffrey Haessler,Carl D. Langefeld,Rebecca F. Gottesman,Kristine Yaffe,Yong Mei Liu,Charles Kooperberg,Leslie A. Lange,Karen L. Furie,Donna K. Arnett,Oscar R. Benavente,Raji P. Grewal,Leema Reddy Peddareddygari,Kristian Hveem,S. Lindstrom,Lu Wang,Erin N. Smith,William J. Gordon,Astrid van Hylckama Vlieg,Mariza de Andrade,Jennifer A. Brody,Jack Pattee,Ben Michael Brumpton,Pierre Suchon,Ming-Huei Chen,Kelly A. Frazer,Constance Turman,Marine Germain,James W. MacDonald,S. Braekkan,Sebastian M. Armasu,Nathan Pankratz,Rebecca D. Jackson,Jonas B. Nielsen,Franco Giulianini,Marja Puurunen,Manal Ibrahim,Susan R. Heckbert,Theo K. Bammler,Bryan M. McCauley,Kent D. Taylor,James S. Pankow,Alexander P. Reiner,Maiken Elvestad Gabrielsen,Jean-François Deleuze,Christopher J. O'Donnell,Jihye Kim,Barbara McKnight,Peter Kraft,J. D. Hansen,Frits R. Rosendaal,John A. Heit,Weihong Tan,Pierre-Emmanuel Morange,Andrew Johnson,Christopher Kabrhel,Ewoud J. van Dijk,Peter J. Koudstaal,Gert-Jan Luijckx,Paul J. Nederkoorn,Robert J. van Oostenbrugge,Marieke C.H. de Visser,Marieke J.H. Wermer,L. Jaap Kappelle,Tõnu Andres Reedik Mari Esko Metspalu Mägi Nelis,Tõnu Esko,Andres Metspalu,Reedik Mägi,Mari Nelis,Marguerite R. Irvin,F.E. De Leeuw,Christopher R Levi,Jane Maguire,Jordi Jimenez-Conde,Pankaj Sharma,Cathie Sudlow,Kristiina Rannikmäe,Reinhold Schmidt,Agnieszka Slowik,Joanna Pera,Vincent Thijs,Arne Lindgren,Andreea Ilinca,Olle Melander,Gunnar Engström,Kathryn M. Rexrode,Peter M. Rothwell,Tara M. Stanne,Julie A. Johnson,John Danesh,Adam S. Butterworth,Laura Heitsch,Giorgio B. Boncoraglio,Michiaki Kubo,Alessandro Pezzini,Arndt Rolfs,Anne-Katrin Giese,David R. Weir,Owen A. Ross,Robert Lemmons,Martin Soderholm,Mary Cushman,K. Joo,Caitrin W. McDonough,Steven Bell,Birgit Linkohr,Tsong-Hai Lee,Jukka Putaala,Christopher D. Anderson,Oscar L. Lopez,Xueqiu Jian,Ulf Schminke,Natalia Cullell,Pilar Delgado,Laura Ibanez,Jerzy Krupinski,Vasileios-Arsenios Lioutas,Koichi Matsuda,Joan Antoni Martín Montaner,Elena Muiño,Jaume Roquer,Chloé Sarnowski,Naveed Sattar,Gerli Sibolt,Alexander Teumer,Loes C.A. Rutten-Jacobs,Masahiro Kanai,Solveig Gretarsdottir,Natalia S. Rost,Salim Yusuf,Peter Almgren,Hakan Ay,Steve Bevan,Robert Brown,Caty Carrera,Julie E. Buring,Wei-Min Chen,Ioana Cotlarciuc,Paul I.W. de Bakker,Anita L. DeStefano,Marcel den Hoed,Qing Duan,Stefan T. Engelter,Guido J. Falcone,Stefan Gustafsson,A Hassan,Elizabeth G. Holliday,George Howard,Fang-Chi Hsu,Erik Ingelsson,Tamara B. Harris,Brett M. Kissela,Dawn Kleindorfer,Claudia Langenberg,Robin Lemmens,Didier Leys,Wei-Yu Lin,Erik Lorentzen,Patrik K. E. Magnusson,Patrick F. McArdle,Sara L. Pulit,Kenneth Rice,Saori Sakaue,Bishwa Raj Sapkota,Christian Tanislav,Gudmar Thorleifsson,Unnur Thorsteinsdottir,Christophe Tzourio,Cornelia M. van Duijn,M. Walters,Nicholas J. Wareham,Najaf Amin,Hugo J. Aparicio,John Attia,Alexa S. Beiser,Claudine Berr,Mariana Bustamante,Valeria Caso,Seung Hoan Choi,Ayesha Chowhan,Jean-François Dartigues,Hossein Delavaran,Marcus Dörr,Ian J. Ford,Wander S. Gurpreet,Anders Hamsten,Atsushi Hozawa,Martin Ingelsson,Motoki Iwasaki,Sara Kaffashian,Lalit Kalra,Olafur Kjartansson,Manja Kloss,Daniel L. Labovitz,Cathy C. Laurie,Linxin Li,Lars Lind,Cecilia M. Lindgren,Hirata Makoto,Naoko Minegishi,Andrew P. Morris,Martina Müller-Nurasyid,Bo Norrving,Soichi Ogishima,Eugenio Parati,Nancy L. Pedersen,Markus Perola,Pekka Jousilahti,Silvana Pileggi,Raquel Rabionet,Iolanda Riba-Llena,Marta Ribasés,Jose R. Romero,Anthony Rudd,Antti-Pekka Sarin,Ralhan Sarju,Mamoru Satoh,Norie Sawada,Asgeir Sigurdsson,O. Colin Stine,David J. Stott,Konstantin Strauch,Takako Takai,Hideo Tanaka,Emmanuel Touzé,Shoichiro Tsugane,André G. Uitterlinden,Einar M. Valdimarsson,S. J. van der Lee,Kenji Wakai,Stephen E. Williams,Charles D.A. Wolfe,Quenna Wong,Taiki Yamaji,Dharambir K. Sanghera,Kari Stefansson,Nicolas Martinez-Majander,Kenji Sobue,Carolina Soriano-Tárraga,Henry Völzke,Onoja Akpa,Fred Stephen Sarfo,Albert Akpalu,Reginald Obiako,Kolawole Wahab,Godwin Osaigbovo,Lukman Owolabi,Morenikeji A. Komolafe,Carolyn Jenkins,Oyedunni Arulogun,Godwin Ogbole,Abiodun M. Adeoye,Joshua O. Akinyemi,Atinuke M Agunloye,Adekunle Fakunle,Ezinne Uvere,Abimbola Olalere,Olayinka J. Adebajo,Junshi Chen,Robert Clarke,Rory Collins,Yu Guo,Chen Wang,Jun Lv,Richard Peto,Yiping Shen,Zammy Fairhurst-Hunter,Michael Hill,Alfred Pozarickij,Dan Schmidt,Becky Stevens,Iain Turnbull,Canqing Yu,Quentin Leslie E. Le Grand Ferreira,Quentin Le Grand,Leslie Ecker Ferreira,Akiko Yoishinori Nagai Murakami,Akiko Nagai,Yoishinori Murakami,M. van Vugt,Eric J. Shiroma,Sigurdur Sigurdsson,Mohsen Ghanbari,Eric Boerwinkle,Bernard Fongang,Ruiqi Wang,Mohammad Kamran Ikram,Uwe Völker,Philip L. De Jager,Børge G. Nordestgaard,Karlijn F. de Laat,Anouk G.W. van Norden,Paul L.M. de Kort,Sarah E. Vermeer,P. J. A. M. Brouwers,Rob A.R. Gons,Tom den Heijer,Gert W. van Dijk,Frank G. van Rooij,Anne Hege Aamodt,Anne Heidi Skogholt,Cristen J. Willer,Ingrid Heuch,Knut Hagen,Lars G. Fritsche,Linda M. Pedersen,Hanne Ellekjær,Wei Zhou,Amy E Martinsen,Espen Saxhaug Kristoffersen,Laurent F. Thomas,Christoph Stefan Kathrin Kleinschnitz Frantz Ungethüm,Christoph Kleinschnitz,Stefan Frantz,K. Ungethüm,Cristina Gallego-Fabrega,Miquel Lledós,Laia Llucià-Carol,Tomás Sobrino,Francisco Campos,José Castillo,M. Freijo,Juan F. Arenillas,Victor Obach,José Alvarez-Sabín,Carlos A. Molina,Marc Ribó,Lucia Muñoz-Narbona,E. López-Cancio,Mónica Millán,Rosa Díaz-Navarro,Cristofol Vives-Bauza,G. Serrano-Heras,Tomás Segura,Rajat Dhar,Raquel Delgado-Mederos,Luis Prats-Sánchez,Pol Camps-Renom,Natalia Blay,Lauro Sumoy,Joan Martí-Fàbregas,Peter Gorm B. Marianne Shoaib Pia R. Schnohr Jensen Benn Afzal Kamstrup,Peter Schnohr,Gorm B. Jensen,Marianne Benn,Shoaib Afzal,Pia R. Kamstrup,Jessica Sander W. Jet M. J. van Setten van der Laan Vonk,Jessica van Setten,Sander W. van der Laan,Jet M.J. Vonk,Bong-Jo Kim,Sami Marjaana Janne Curtze Tiainen Kinnunen,S. Curtze,Marjaana Tiainen,Janne Kinnunen,Vilas Yun Ju Chengran Florence Simon Menon Sung Yang Saillour-Glenisson Gravel,Vilas Menon,Yun Ju Sung,Chengran Yang,Florence Saillour-Glénisson,Simon Gravel,N. C. A. K. Onland-Moret Heath,Iona Y. Millwood,Christian Gieger,Toshiharu Ninomiya,Hans J. Grabe,J. Wouter Jukema,Ina Rissanen,Daniel Strbian,Young-Jin Kim,Pei-Hsin Chen,E. Mayerhofer,Joanna M. M. Howson,Hieab H.H. Adams,Sylvia Wassertheil-Smoller,Kaare Christensen,M. Arfan Ikram,Tatjana Rundek,Bradford B. Worrall,Mark Lathrop,Moeen Riaz,Eleanor M. Simonsick,Janika Kõrv,Paulo Henrique Condeixa de França,Ramin Zand,Kameshwar Prasad,Ruth Frikke-Schmidt,Thomas G. Liman,Karl Georg Haeusler,Ynte M. Ruigrok,Peter U. Heuschmann,W. T. Longstreth,Keum Ji Jung,L. Bastarache,Guillaume Paré,Scott M. Damrauer,Daniel I. Chasman,Jerome I. Rotter,John-Anker Zwart,Teemu J. Niiranen,Myriam Fornage,Yung-Po Liaw,Sudha Seshadri,Israel Fernandez-Cadenas,Robin G. Walters,Christian T. Ruff,Mayowa O. Owolabi,Jennifer E. Huffman,Lili Milani,Yoichiro Kamatani,Martin Dichgans,Stéphanie Debette +551 more
TL;DR: In this article , a cross-ancestry GWAS meta-analyses of 110,182 patients who have had a stroke (five ancestries, 33% non-European) and 1,503,898 control individuals, identify association signals for stroke and its subtypes at 89 (61 new) independent loci: 60 in primary inverse-variance-weighted analyses and 29 in secondary meta-regression and multitrait analyses.
Discovery and prioritization of variants and genes for kidney function in >1.2 million individuals.
Kira J Stanzick,Yong Li,Pascal Schlosser,Mathias Gorski,Matthias Wuttke,Laurent F. Thomas,Humaira Rasheed,Humaira Rasheed,Bryce X Rowan,Bryce X Rowan,Sarah E. Graham,Brett R Vanderweff,Snehal Patil,VA Million Veteran Program,VA Million Veteran Program,Cassiane Robinson-Cohen,Cassiane Robinson-Cohen,John Michael Gaziano,John Michael Gaziano,Christopher J. O'Donnell,Cristen J. Willer,Stein Hallan,Bjørn Olav Åsvold,André Gessner,Adriana M. Hung,Adriana M. Hung,Cristian Pattaro,Anna Köttgen,Anna Köttgen,Klaus Stark,Iris M. Heid,Thomas W. Winkler +31 more
TL;DR: In this paper, the authors meta-analyze kidney function genome-wide association studies to identify new loci and fine-map loci to home in on variants and genes involved in kidney function.
Circular RNAs are depleted of polymorphisms at microRNA binding sites.
Laurent F. Thomas,Pål Sætrom +1 more
TL;DR: Using SNP data from the 1000 Genomes Project, a significant decrease in SNP density was found at miRNA seed sites compared with flanking sequences and random sites, suggesting that many of the predicted miRNA binding sites in circRNAs are functional and under similar selective pressure as miRNAs in mRNAs.