Laurent Brault
University Hospital of Basel
14 Papers
57 Citations
Laurent Brault is an academic researcher from University Hospital of Basel. The author has contributed to research in topics: Haematopoiesis & Kinase. The author has an hindex of 10, co-authored 13 publications. Previous affiliations of Laurent Brault include Boston Children's Hospital.
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Papers
PIM serine/threonine kinases in the pathogenesis and therapy of hematologic malignancies and solid cancers
TL;DR: Current knowledge about the role of PIM serine/threonine kinases for the pathogenesis and therapy of hematologic malignancies and solid cancers is summarized, structural principles and recent progress on small molecule PIM kinase inhibitors that are on their way into first clinical trials are highlighted.
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MLL-AF9 Expression in Hematopoietic Stem Cells Drives a Highly Invasive AML Expressing EMT-Related Genes Linked to Poor Outcome
Vaia Stavropoulou,Susanne Kaspar,Susanne Kaspar,Laurent Brault,Mathijs A. Sanders,Sabine Juge,Stefano Morettini,Alexandar Tzankov,Michelina Iacovino,I-Jun Lau,Thomas A. Milne,Hélène Royo,Michael Kyba,Peter J. M. Valk,Antoine H.F.M. Peters,Antoine H.F.M. Peters,Juerg Schwaller +16 more
TL;DR: By classifying mouse and human leukemias according to Evi1/EVI1 and Erg/ERG expression, reflecting aggressiveness and cell of origin, and performing comparative transcriptomics, several EMT-related genes were identified that were significantly associated with poor overall survival of AML patients.
214
High-throughput kinase profiling: a more efficient approach toward the discovery of new kinase inhibitors.
Chandrasekhar V. Miduturu,Xianming Deng,Nicholas Kwiatkowski,Wannian Yang,Laurent Brault,Panagis Filippakopoulos,Eunah Chung,Qingkai Yang,Juerg Schwaller,Stefan Knapp,Randall W. King,Jiing Dwan Lee,Sanna Herrgard,Patrick P. Zarrinkar,Nathanael S. Gray +14 more
TL;DR: It is demonstrated that "high-throughput kinase profiling" is an efficient method for the discovery of lead compounds for established as well as unexplored kinase targets and represents an efficient and general strategy for identifying new selective kinase inhibitors.
138
7,8-dichloro-1-oxo-β-carbolines as a versatile scaffold for the development of potent and selective kinase inhibitors with unusual binding modes.
Kilian Huber,Laurent Brault,Oleg Fedorov,Christelle Gasser,Panagis Filippakopoulos,Alex N. Bullock,Doriano Fabbro,Jörg Trappe,Jürg Schwaller,Stefan Knapp,Franz Bracher +10 more
TL;DR: A novel class of substituted 7,8-dichloro-1-oxo-β-carbolines based on the distinct structural features of the alkaloid bauerine C whose kinase inhibitory activity does not rely on canonical ATP-mimetic hinge interactions is presented.
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Functional characterization of high levels of meningioma 1 as collaborating oncogene in acute leukemia.
Ting Liu,Dragana Jankovic,Laurent Brault,Sabine Ehret,Florent Baty,Vaia Stavropoulou,Vincenzo Rossi,Andrea Biondi,Juerg Schwaller +8 more
TL;DR: It is shown for the first time that high MN1 levels are important for the growth of leukemic cells, and that increased MN1 expression can synergize with MLL-ENL and probably other transforming fusion genes in leukemia induction through a distinct gene expression program that is able to expand the leukemia-initiating cell population.
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