Laurence Philippe
Pfizer
15 Papers
133 Citations
Laurence Philippe is an academic researcher from Pfizer. The author has contributed to research in topics: Chemistry & Supercritical fluid chromatography. The author has an hindex of 10, co-authored 15 publications.
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Papers
Chemical and Computational Methods for the Characterization of Covalent Reactive Groups for the Prospective Design of Irreversible Inhibitors
Mark Edward Flanagan,Joseph A. Abramite,Dennis P. Anderson,Ann Aulabaugh,Upendra P. Dahal,Adam M. Gilbert,Chao Li,Justin I. Montgomery,Stacey R. Oppenheimer,Tim F. Ryder,Brandon P. Schuff,Daniel P. Uccello,Gregory S. Walker,Yan Wu,Matthew Frank Brown,Jinshan M. Chen,Matthew Merrill Hayward,Mark C. Noe,R. Scott Obach,Laurence Philippe,Veerabahu Shanmugasundaram,Michael J. Shapiro,Jeremy T. Starr,Justin G. Stroh,Ye Che +24 more
TL;DR: Methods for measuring the reactivity of covalent reactive groups (CRGs) with a biologically relevant nucleophile, glutathione (GSH), along with kinetic data for a broad array of electrophiles are described.
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EPSA: A Novel Supercritical Fluid Chromatography Technique Enabling the Design of Permeable Cyclic Peptides
TL;DR: A supercritical fluid chromatography technique for peptides, termed EPSA, is developed, which is shown here to enable improved permeability design, through assessing the exposed polarity of a peptide, which can be used as a permeability surrogate.
136
High Throughput Method for the Indirect Detection of Intramolecular Hydrogen Bonding
Gilles H. Goetz,William Farrell,Marina Shalaeva,Simone Sciabola,Dennis P. Anderson,Jiangli Yan,Laurence Philippe,Michael J. Shapiro +7 more
TL;DR: A supercritical fluid chromatography method was developed for the detection of intramolecular hydrogen bonds in pharmaceutically relevant molecules and correlates chromatographic retention with the exposed polarity of a molecule.
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Integrating Intramolecular Hydrogen Bonding (IMHB) Considerations in Drug Discovery Using ΔlogP As a Tool
Marina Shalaeva,Giulia Caron,Yuriy A. Abramov,Thomas N. O'Connell,Mark S. Plummer,Geeta Yalamanchi,Kathleen A. Farley,Gilles H. Goetz,Laurence Philippe,Michael J. Shapiro +9 more
TL;DR: It is demonstrated that ΔlogP(oct-tol) describes compounds propensity to form intramolecular hydrogen bonds (IMHB) and may be considered a privileged molecular descriptor for use in drug discovery and for prediction of IMHB in drug candidates.
Biaryl-Bridged Macrocyclic Peptides: Conformational Constraint via Carbogenic Fusion of Natural Amino Acid Side Chains
Falco-Magnus Meyer,James C. Collins,Brendan Borin,James Bradow,Spiros Liras,Chris Limberakis,Alan M. Mathiowetz,Laurence Philippe,David Price,Kun Song,Keith James +10 more
TL;DR: This approach constitutes a means of constraining peptide conformation via direct carbogenic fusion of side chains of naturally occurring amino acids such as phenylalanine and tyrosine, and so is complementary to strategies involving non-natural, for example, hydrocarbon, bridges.
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