Laurence Legros
French Institute of Health and Medical Research
207 Papers
1K Citations
Laurence Legros is an academic researcher from French Institute of Health and Medical Research. The author has contributed to research in topics: Imatinib mesylate & Medicine. The author has an hindex of 38, co-authored 186 publications. Previous affiliations of Laurence Legros include Centre national de la recherche scientifique & University of Nice Sophia Antipolis.
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Papers
Targeting STAT5 Expression Resulted in Molecular Response Improvement in Patients with Chronic Phase CML Treated with Imatinib
Philippe Rousselot,Lydia Roy,Gabriel Etienne,Laurence Legros,Aude Charbonnier,Valérie Coiteux,Pascale Cony-Makhoul,Francois-Xavier Mahon,Joelle Guilhot,Jean-Michel Cayuela,Francis Relouzat,Philippe Leboulche,Stéphane Prost +12 more
TL;DR: It is demonstrated that pioglitazone at pharmacological doses inhibited cell growth of the Bcr-Abl positive cell line K562 through the activation of the PPAR-g/STAT5 pathway and induced a clonogenic defect in CD34+ cells from CML patients.
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Carfilzomib weekly 20/56 mg/m2 , lenalidomide and dexamethasone for early relapsed refractory multiple myeloma.
Valentine Richez,Cécile Gruchet,Stéphanie Guidez,Guillemette Fouquet,Isabelle Azais,Geraldine Durand,Vincent Javaugue,Antoine Brigaud,Florent Plasse,Jeremie Diolez,Antoine Machet,Niels Moya,Helene Gardeney,Paul Franques,Arthur Bobin,Anthony Levy,Florence Sabirou,Anthony Bonnin,Celine Dieval,Sylvain Primault,Jocelyn Barrier,Emmanuel Fleck,Sabrina Bouyier,Claire Daras,Isabelle Princet,Delphine Bauwens,Laurence Legros,Jean-Gabriel Fuzibet,Angela Gil,Frank Bridoux,Hervé Avet-Loiseau,Xavier Leleu +31 more
TL;DR: Results indicated that improved patient-reported outcomes, especially increased adherence, are significant mediators of the association between treatment with deferasirox DT vs FCT, and the reduction from baseline in serum ferritin achieved over 6 months of treatment.
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Onset of blast crisis in chronic myeloid leukemia patients in treatment-free remission
Stéphanie Dulucq,Sandrine Hayette,Jean-Michel Cayuela,Frédéric Bauduer,Kaddour Chabane,P. Chevallier,Pascale Cony-Makhoul,Pascale Flandrin-Gresta,Yannick Le Bris,Laurence Legros,Hervé Maisonneuve,Lydia Roy,Francois-Xavier Mahon,Ivan Sloma,Delphine Rea,Franck E. Nicolini +15 more
TL;DR: In this paper , the authors propose a method to solve the problem of "not available" data: https://www.youtube.com/watch/watch?feature=youtu.
Improved Outcome with Androgens as Maintenance Treatment in Elderly Patients with Acute Myeloid Leukemia after ICL Regimen as Induction Therapy: Results of the GOELAMS SA-2002 Multicenter Phase III Randomized Open Trial
Arnaud Pigneux,Chantal Himberlin,Mathilde Hunault-Berger,Francis Witz,Christian Recher,Jean-Luc Harousseau,Olivier Tournilhac,Christian Berthou,Martine Escoffre-Barbe,Denis Guyotat,Nathalie Fegueux,Martine Delain,Bruno Lioure,Eric Jourdan,Didier Bouscary,Laurence Legros,Noel Milpied,Frédéric Bauduer,Frederic Perry,Isabelle Luquet,Marie-Christine Béné,Norbert Ifrah,Jean-Jacques Sotto,Philippe Guardiola +23 more
TL;DR: The French group, GOELAMS, performed a multicenter phase III randomized open trial to evaluate whether adding androgens to post-remission induction therapy was associated with an improved outcome in elderly pts with de novo AML; especially in those achieving CR and remaining in remission for at least a year.
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Stratégies thérapeutiques et recommandations pour la prise en charge des patients atteints de leucémie myéloïde chronique
Dominique Bories,Agnès Devergie,Martine Gardembas-Pain,Mathieu Kuentz,Laurence Legros,Francois-Xavier Mahon,Franck E. Nicolini,Claude Preudhomme,Sophie Raynaud,Françoise Rigal-Huguet,Philippe Rousselot,Ali G. Turhan,Jacqueline Van Den Akker,François Guilhot +13 more
- 01 Nov 2003
TL;DR: Auteur(s) :Dominique Bories, Agnes Devergie, Martine Gardembas-Pain, Mathieu Kuentz, Laurence Legros, Francois-Xavier Mahon, Franck Nicolini, Claude Preudhomme, Sophie Raynaud, Francoise Rigal-Huguet, Philippe Rousselot, Ali Turhan, Jacqueline Van Den Akker.
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