Laurence Leconte
Centre national de la recherche scientifique
4 Papers
33 Citations
Laurence Leconte is an academic researcher from Centre national de la recherche scientifique. The author has contributed to research in topics: Transgene & Gene. The author has an hindex of 3, co-authored 4 publications.
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Papers
Both upstream and intragenic sequences of the human neurofilament light gene direct expression of lacZ in neurons of transgenic mouse embryos
Laurence Leconte,Olivier Semonin,Agnès Zvara,Agnès Zvara,Boisseau S,Chantal Poujeol,Jean-Pierre Julien,Michel Simonneau +7 more
TL;DR: Results show that the neurofilament light gene contains separate upstream and intragenic elements, each of which directslacZ expression in embryonic neurons, and concludes that these hNF-L intragenics sequences containcis-acting DNA regulatory elements that specify neuronal expression.
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Cell type-specific expression of the mouse peripherin gene requires both upstream and intragenic sequences in transgenic mouse embryos
Laurence Leconte,Miklos Santha,Cecile Fort,Chantal Poujeol,Marie Madeleine Portier,Michel Simonneau +5 more
TL;DR: Analysis of transgenic mouse lines expressing the construct containing both upstream and intragenic sequences showed that this transgene contains all regulatory elements essential for both spatial and temporal expression of the mouse peripherin gene during embryogenesis.
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Patent
mutated netrin 4 proteins, fragments thereof and their uses as drugs
Laurence Leconte,Esma Lejmi,Jean Plouët +2 more
- 16 Jul 2009
TL;DR: In this article, the present invention relates to a mutated protein comprising or consisting of the sequence of wild type netrin 4, represented by SEQ ID NO : 2, wherein at least one amino acid of the amino acids at position (13, 68, 183, 205, 234, 234 and 331, 332, 353, 472, 515, 589, 625, 626, 627) and (628) is mutated enabling thus to confer 1 to 15 mutations to said wild type protein, or, truncated protein derived from said mutated protein, wherein the
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•Journal Article
A mammalian in vitro model to study gangliogenesis from neural crest cells.
Boisseau S,Poirier,Semonin O,Laurence Leconte,Santha M,Chantal Poujeol,G. Rougon,Michel Simonneau +7 more
TL;DR: A novel mammalian in vitro model permitting to study gangliogenesis from neural crest cells is presented, which allowed us to manipulate molecules involved in cell-cell interactions and supported the existence of a hierarchy among adhesion molecules.
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