Lauren Young
Foundation Medicine
36 Papers
90 Citations
Lauren Young is an academic researcher from Foundation Medicine. The author has contributed to research in topics: Medicine & Gene. The author has an hindex of 18, co-authored 34 publications. Previous affiliations of Lauren Young include Broad Institute & Brown University.
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Papers
Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies
Cathy E. Elks,John R. B. Perry,Patrick Sulem,Daniel I. Chasman,Nora Franceschini,Chunyan He,Kathryn L. Lunetta,Kathryn L. Lunetta,Jenny A. Visser,Enda M. Byrne,Enda M. Byrne,Diana L. Cousminer,Daniel F. Gudbjartsson,Tõnu Esko,Bjarke Feenstra,Jouke-Jan Hottenga,Daniel L. Koller,Zoltán Kutalik,Zoltán Kutalik,Peng Lin,Massimo Mangino,Mara Marongiu,Patrick F. McArdle,Albert V. Smith,Lisette Stolk,Sophie H. Van Wingerden,Jing Hua Zhao,Eva Albrecht,Tanguy Corre,Erik Ingelsson,Caroline Hayward,Patrik K. E. Magnusson,Erin N. Smith,Erin N. Smith,S. Ulivi,Nicole M. Warrington,Lina Zgaga,Helen Alavere,Najaf Amin,Thor Aspelund,Stefania Bandinelli,Inês Barroso,Gerald S. Berenson,Sven Bergmann,Sven Bergmann,Hannah Blackburn,Eric Boerwinkle,Julie E. Buring,Fabio Busonero,Harry Campbell,Stephen J. Chanock,Wei Chen,Marilyn C. Cornelis,David Couper,Andrea D. Coviello,Pio D'Adamo,Ulf de Faire,Eco J. C. de Geus,Panos Deloukas,Angela Döring,George Davey Smith,Douglas F. Easton,Gudny Eiriksdottir,Valur Emilsson,Johan G. Eriksson,Johan G. Eriksson,Luigi Ferrucci,Aaron R. Folsom,Tatiana Foroud,Melissa E. Garcia,Paolo Gasparini,Frank Geller,Christian Gieger,Vilmundur Gudnason,Per Hall,Susan E. Hankinson,Liana Ferreli,Andrew C. Heath,Dena G. Hernandez,Albert Hofman,Frank B. Hu,Thomas Illig,Marjo-Riitta Järvelin,Andrew D. Johnson,David Karasik,Kay-Tee Khaw,Douglas P. Kiel,Tuomas O. Kilpelänen,Ivana Kolcic,Peter Kraft,Lenore J. Launer,Joop S.E. Laven,Shengxu Li,Jianjun Liu,Daniel Levy,Daniel Levy,Nicholas G. Martin,Wendy L. McArdle,Mads Melbye,Vincent Mooser,Jeffrey C. Murray,Sarah S. Murray,Sarah S. Murray,Mike A. Nalls,Pau Navarro,Mari Nelis,Andy R Ness,Kate Northstone,Ben A. Oostra,Munro Peacock,Lyle J. Palmer,Aarno Palotie,Aarno Palotie,Aarno Palotie,Guillaume Paré,Guillaume Paré,Alex Parker,Nancy L. Pedersen,Leena Peltonen,Craig E. Pennell,Paul D.P. Pharoah,Ozren Polasek,Andrew S. Plump,Anneli Pouta,Eleonora Porcu,Thorunn Rafnar,John P. Rice,Susan M. Ring,Fernando Rivadeneira,Igor Rudan,Igor Rudan,Cinzia Sala,Veikko Salomaa,Serena Sanna,David Schlessinger,Nicholas J. Schork,Nicholas J. Schork,Angelo Scuteri,Ayellet V. Segrè,Ayellet V. Segrè,Alan R. Shuldiner,Alan R. Shuldiner,Nicole Soranzo,Nicole Soranzo,Ulla Sovio,Sathanur R. Srinivasan,David P. Strachan,Mar Liis Tammesoo,Emmi Tikkanen,Emmi Tikkanen,Daniela Toniolo,Kim Tsui,Laufey Tryggvadottir,Tyrer Jp,Manuela Uda,Rob M. van Dam,Rob M. van Dam,Joyce B. J. van Meurs,Peter Vollenweider,Gérard Waeber,Nicholas J. Wareham,Dawn M. Waterworth,Michael N. Weedon,H.-Erich Wichmann,Gonneke Willemsen,James F. Wilson,Alan F. Wright,Lauren Young,Guangju Zhai,Wei Vivian Zhuang,Laura J. Bierut,Dorret I. Boomsma,Heather A. Boyd,Laura Crisponi,Ellen W. Demerath,Cornelia M. van Duijn,Michael J. Econs,Tamara B. Harris,David J. Hunter,David J. Hunter,Ruth J. F. Loos,Andres Metspalu,Grant W. Montgomery,Paul M. Ridker,Tim D. Spector,Elizabeth A. Streeten,Kari Stefansson,Kari Stefansson,Unnur Thorsteinsdottir,Unnur Thorsteinsdottir,André G. Uitterlinden,Elisabeth Widen,Joanne M. Murabito,Joanne M. Murabito,Ken K. Ong,Ken K. Ong,Anna Murray +196 more
TL;DR: A meta-analysis of 32 genome-wide association studies in 87,802 women of European descent found 30 new menarche loci and found suggestive evidence for a further 10 loci, including four previously associated with body mass index and three in or near genes implicated in hormonal regulation.
Meta-analysis of genome-wide association studies in >80,000 subjects identifies multiple loci for C-reactive protein levels
Abbas Dehghan,Josée Dupuis,Josée Dupuis,Maja Barbalić,Joshua C. Bis,Gudny Eiriksdottir,Chen Lu,Niina Pellikka,Henri Wallaschofski,Johannes Kettunen,Peter Henneman,Jens Baumert,David P. Strachan,Christian Fuchsberger,Veronique Vitart,James F. Wilson,Guillaume Paré,Silvia Naitza,Megan E. Rudock,Ida Surakka,Eco J. C. de Geus,Behrooz Z. Alizadeh,Jack M. Guralnik,Alan R. Shuldiner,Toshiko Tanaka,Robert Y.L. Zee,Renate B. Schnabel,Vijay Nambi,Maryam Kavousi,Samuli Ripatti,Matthias Nauck,Nicholas L. Smith,Albert V. Smith,Jouko Sundvall,Paul Scheet,Yongmei Liu,Aimo Ruokonen,Lynda M. Rose,Martin G. Larson,Martin G. Larson,Ron C. Hoogeveen,Nelson B. Freimer,Alexander Teumer,Russell P. Tracy,Lenore J. Launer,Julie E. Buring,Jennifer F. Yamamoto,Jennifer F. Yamamoto,Aaron R. Folsom,Eric J.G. Sijbrands,James S. Pankow,Paul Elliott,John F. Keaney,John F. Keaney,Wei Sun,Antti-Pekka Sarin,João D. Fontes,João D. Fontes,Sunita Badola,Brad C. Astor,Albert Hofman,Anneli Pouta,Karl Werdan,Karin Halina Greiser,Karin Halina Greiser,Oliver Kuss,Henriette E. Meyer zu Schwabedissen,Joachim Thiery,Yalda Jamshidi,Yalda Jamshidi,Ilja M. Nolte,Nicole Soranzo,Tim D. Spector,Henry Völzke,Alex Parker,Thor Aspelund,David W. Bates,Lauren Young,Kim Tsui,David S. Siscovick,Xiuqing Guo,Jerome I. Rotter,Manuela Uda,David Schlessinger,Igor Rudan,Igor Rudan,Andrew A. Hicks,Brenda W.J.H. Penninx,Barbara Thorand,Christian Gieger,Joe Coresh,Gonneke Willemsen,Tamara B. Harris,André G. Uitterlinden,Marjo-Riitta Järvelin,Kenneth Rice,Dörte Radke,Veikko Salomaa,Ko Willems van Dijk,Eric Boerwinkle,Ramachandran S. Vasan,Luigi Ferrucci,Quince Gibson,Stefania Bandinelli,Harold Snieder,Dorret I. Boomsma,Xiangjun Xiao,Harry Campbell,Caroline Hayward,Peter P. Pramstaller,Cornelia M. van Duijn,Leena Peltonen,Bruce M. Psaty,Vilmundur Gudnason,Paul M. Ridker,Georg Homuth,Wolfgang Koenig,Christie M. Ballantyne,Jacqueline C.M. Witteman,Emelia J. Benjamin,Markus Perola,Daniel I. Chasman +121 more
TL;DR: A genome-wide association analysis of CRP identified 18 loci that were associated with CRP levels and highlighted immune response and metabolic regulatory pathways involved in the regulation of chronic inflammation.
Meta-Analysis of Genome-Wide Association Studies in > 80 000 Subjects Identifies Multiple Loci for C-Reactive Protein Levels
Abbas Dehghan,Josée Dupuis,Maja Barbalić,Joshua C. Bis,Gudny Eiriksdottir,Chen Lu,Niina Pellikka,Henri Wallaschofski,Johannes Kettunen,Peter Henneman,Jens Baumert,David P. Strachan,Christian Fuchsberger,Veronique Vitart,James F. Wilson,Guillaume Paré,Silvia Naitza,Megan E. Rudock,Ida Surakka,Eco J. C. de Geus,Behrooz Z. Alizadeh,Jack M. Guralnik,Alan R. Shuldiner,Toshiko Tanaka,Robert Y.L. Zee,Renate B. Schnabel,Vijay Nambi,Maryam Kavousi,Samuli Ripatti,Matthias Nauck,Nicholas L. Smith,Albert V. Smith,Jouko Sundvall,Paul Scheet,Yongmei Liu,Aimo Ruokonen,Lynda M. Rose,Martin G. Larson,Ron C. Hoogeveen,Nelson B. Freimer,Alexander Teumer,Russell P. Tracy,Lenore J. Launer,Julie E. Buring,Jennifer F. Yamamoto,Aaron R. Folsom,Eric J.G. Sijbrands,James S. Pankow,Paul Elliott,John F. Keaney,Wei Sun,Antti-Pekka Sarin,João D. Fontes,Sunita Badola,Brad C. Astor,Albert Hofman,Anneli Pouta,Karl Werdan,Karin Halina Greiser,Oliver Kuss,Henriette E. Meyer zu Schwabedissen,Joachim Thiery,Yalda Jamshidi,Ilja M. Nolte,Nicole Soranzo,Tim D. Spector,Henry Voelzke,Alex Parker,Thor Aspelund,David W. Bates,Lauren Young,Kim Tsui,David S. Siscovick,Xiuqing Guo,Jerome I. Rotter,Manuela Uda,David Schlessinger,Igor Rudan,Andrew A. Hicks,Brenda W.J.H. Penninx,Barbara Thorand,Christian Gieger,Joe Coresh,Gonneke Willemsen,Tamara B. Harris,André G. Uitterlinden,Marjo-Riitta Järvelin,Kenneth Rice,Doerte Radke,Veikko Salomaa,Ko Willems van Dijk,Eric Boerwinkle,Ramachandran S. Vasan,Luigi Ferrucci,Quince Gibson,Stefania Bandinelli,Harold Snieder,Dorret I. Boomsma,Xiangjun Xiao,Harry Campbell,Caroline Hayward,Peter P. Pramstaller,Cornelia M. van Duijn,Leena Peltonen,Bruce M. Psaty,Vilmundur Gudnason,Paul M. Ridker,Georg Homuth,Wolfgang Koenig,Christie M. Ballantyne,Jacqueline C.M. Witteman,Emelia J. Benjamin,Markus Perola,Daniel I. Chasman +113 more
- 01 Jan 2011
462
Directed evolution of adenine base editors with increased activity and therapeutic application.
Nicole M. Gaudelli,Dieter K. Lam,Holly A. Rees,Noris M. Solá-Esteves,Luis A. Barrera,David A. Born,Aaron Edwards,Jason Michael Gehrke,Seung-Joo Lee,Alexander Liquori,Ryan Murray,Michael S. Packer,Conrad Rinaldi,Ian Slaymaker,Jonathan Yen,Lauren Young,Giuseppe Ciaramella +16 more
TL;DR: In primary human T cells, ABE8s achieve 98–99% target modification, which is maintained when multiplexed across three loci, and in human CD34 + cells, Abe8 can recreate a natural allele at the promoter of the γ-globin genes HBG1 and HBG2 with up to 60% efficiency.
The malaria parasite Plasmodium vivax exhibits greater genetic diversity than Plasmodium falciparum
Daniel E. Neafsey,Kevin Galinsky,Rays H. Y. Jiang,Lauren Young,Sean M. Sykes,Sakina Saif,Sharvari Gujja,Jonathan M. Goldberg,Sarah Young,Qiandong Zeng,Sinéad B. Chapman,Aditya P Dash,Anupkumar R. Anvikar,Patrick L. Sutton,Bruce W. Birren,Ananias A. Escalante,John W. Barnwell,Jane M. Carlton +17 more
TL;DR: The sequenced and annotated the genomes of four P. vivax strains collected from disparate geographic locations, tripling the number of genome sequences available for this understudied parasite and providing the first genome-wide perspective of global variability in this species.