Lauren Segall
Concordia University
5 Papers
1 Citations
Lauren Segall is an academic researcher from Concordia University. The author has contributed to research in topics: PER2 & Central nucleus of the amygdala. The author has an hindex of 4, co-authored 5 publications.
Chat about Author
Papers
Brain glucocorticoid receptors are necessary for the rhythmic expression of the clock protein, PERIOD2, in the central extended amygdala in mice
TL;DR: The results implicate brain GR receptors in the regulation of PER2 expression in the BNSTov and CEA and are consistent with previous findings that the rhythmic expression of perIOD2 in these areas is selectively sensitive to fluctuations in circulating corticosterone.
64
Exogenous Corticosterone Induces the Expression of the Clock Protein, PERIOD2, in the Oval Nucleus of the Bed Nucleus of the Stria Terminalis and the Central Nucleus of the Amygdala of Adrenalectomized and Intact Rats
Lauren Segall,Shimon Amir +1 more
TL;DR: The findings suggest that despite the potential masking effect of signals from the light-entrained master clock, daytime chronic and acute corticosterone administration can alter the rhythmic expression of PER2 in the BNSTov and CEA, and that the response is region-specific and dependent on the duration of treatment.
35
Glucocorticoid rhythms control the rhythm of expression of the clock protein, period2, in oval nucleus of the bed nucleus of the stria terminalis and central nucleus of the amygdala in rats
TL;DR: In rats, in the absence of the adrenals, corticosterone replacement via the drinking water, which is associated with daily fluctuations in cortic testosterone levels, restores the rhythm of Period2 in the oval nucleus of the bed nucleus ofthe stria terminalis and central nucleus ofThe amygdala.
The expression of the clock protein PER2 in the limbic forebrain is modulated by the estrous cycle.
TL;DR: The finding that fluctuations in ovarian hormones have area-specific effects on clock gene expression in the brain introduces a new level of organizational complexity in the control of circadian rhythms of behavior and physiology.