Laurel Romano
Cincinnati Children's Hospital Medical Center
6 Papers
3 Citations
Laurel Romano is an academic researcher from Cincinnati Children's Hospital Medical Center. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 2, co-authored 2 publications.
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Papers
Prevalence of inherited blood disorders and associations with malaria and anemia in Malawian children
Patrick T. McGann,Patrick T. McGann,Anne M Williams,Anne M Williams,Graham Ellis,Graham Ellis,Kathryn E. McElhinney,Laurel Romano,Julia Woodall,Thad A. Howard,Gerald Tegha,Robert Krysiak,R. Murray Lark,E. Louise Ander,Carine Mapango,Kenneth I. Ataga,Kenneth I. Ataga,Satish Gopal,Satish Gopal,Nigel S. Key,Nigel S. Key,Russell E. Ware,Russell E. Ware,Parminder S. Suchdev +23 more
TL;DR: Data from a secondary analysis of the 2015-2016 Malawi Micronutrient Survey document that inherited blood disorders are common and likely play an important role in the prevalence of anemia and malaria in Malawian children.
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Erythroblastic islands foster granulopoiesis in parallel to terminal erythropoiesis.
Laurel Romano,Katie Giger Seu,Julien Papoin,David E. Muench,Diamantis G. Konstantinidis,Andre Olsson,Katrina Schlum,Kashish Chetal,Joel Anne Chasis,Narla Mohandas,Betsy J. Barnes,Yi Zheng,H. Leighton Grimes,Nathan Salomonis,Lionel Blanc,Theodosia A. Kalfa +15 more
TL;DR: These findings demonstrate that EBIs serve a dual role as niches for terminal erythro-(myelo)-blastic islands and granulopoiesis and the central macrophages adapt to optimize production of red blood cells or neutrophils.
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Genetic Causes of Anemia in Malawian Children Less Than 5 Years of Age: Results from the Malawi Demographic and Health Survey
Patrick T. McGann,Anne M Williams,Kathryn E. McElhinney,Laurel Romano,Julia Woodall,Thad A. Howard,Graham Ellis,Carine Mapango,Ben Chilima,Russell E. Ware,Parminder S. Suchdev +10 more
TL;DR: Anemia is a common and multi-factorial problem in Malawia, and nutritional and genetic causes of anemia are common in this study, and alpha-thalassemia status was associated with a significantly lower hemoglobin concentration compared to non-carriers.
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Crosstalk between terminal erythropoiesis and granulopoiesis within their common niche: the erythromyeloblastic island
TL;DR: The role of the EBI macrophage in balance between terminal erythropoiesis and granulocytic precursors has been investigated in this article , where the authors focus on the characteristics and the role of EBI Mϕ balancing the balance between the two macrophages.
De Novo Germline DHX38 Variant Associated with Alternative Splicing of Multiple Transcripts in Iron-Related Pathways in a Patient with Atypical Congenital Dyserythropoietic Anemia with Ring Sideroblasts
Aikaterini Voulgaridou,Yasmin Elgammal,Ammar Husami,Sana Emberesh,Katie Giger Seu,Mahesh Ramamoorthy,Lisa Trump,Nathaniel Barasa,Adam S. Nelson,Robert B. Lorsbach,Laurel Romano,Nathan A. Salomonis,Wenying Zhang,Carolyn Lutzko,Theodosia A. Kalfa +14 more
TL;DR: A 2-year-old female, enrolled in CDAR, had transfusion-dependent anemia since birth and had failure to thrive despite regular transfusions maintaining trough hemoglobin higher than 9.5 g/dL as mentioned in this paper .