Laurel Hoffman
University of Texas Health Science Center at Houston
11 Papers
46 Citations
Laurel Hoffman is an academic researcher from University of Texas Health Science Center at Houston. The author has contributed to research in topics: Calmodulin & Binding site. The author has an hindex of 7, co-authored 11 publications. Previous affiliations of Laurel Hoffman include University of Texas at Austin & Vanderbilt University.
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Papers
Neurogranin Alters the Structure and Calcium Binding Properties of Calmodulin
TL;DR: The binding affinity of Ng for CaM is weakened by Ca2+ but to a lesser extent than that previously suggested from qualitative observations, and the most dramatic biochemical effect is the impact of Ng onCa2+ binding to the C-terminal lobe of CaM.
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Conformational changes underlying calcium/calmodulin-dependent protein kinase II activation
TL;DR: A mechanistic model of the CaMKII holoenzyme grounded in a dynamic understanding of autoregulation that is consistent with a wealth of biochemical and functional data is supported.
Conformational frustration in calmodulin-target recognition.
Swarnendu Tripathi,Swarnendu Tripathi,Qian Wang,Qian Wang,Pengzhi Zhang,Pengzhi Zhang,Laurel Hoffman,M. Neal Waxham,Margaret S. Cheung,Margaret S. Cheung +9 more
TL;DR: The molecular basis of target recognition of CaM with peptides representing the CaM‐binding domains from two Ca2+‐CaM‐dependent kinases, CaMKI and CaMKII, is explored by employing experimentally constrained molecular simulations.
Relative Cosolute Size Influences the Kinetics of Protein-Protein Interactions
Laurel Hoffman,Xu Wang,Hugo Sanabria,Margaret S. Cheung,Margaret S. Cheung,John A. Putkey,M. Neal Waxham +6 more
TL;DR: Insight was gained on how high concentrations of inert crowding agents and osmolytes fit into a kinetic framework to describe protein-protein interactions relevant for cellular signaling.
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Domain Contributions to Signaling Specificity Differences Between Ras-Guanine Nucleotide Releasing Factor (Ras-GRF) 1 and Ras-GRF2
Shan-Xue Jin,Christopher Bartolome,Junko A. Arai,Laurel Hoffman,B. Gizem Uzturk,Rajendra Kumar-Singh,M. Neal Waxham,Larry A. Feig +7 more
TL;DR: These studies revealed a critical role for the GRF2 CDC25 domain in the induction of TBS-LTP by GRF proteins, and showed that specificity is encoded in only one or two domains, and a different set of domains for each form of synaptic plasticity.
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