Laura Willems
Griffith University
19 Papers
194 Citations
Laura Willems is an academic researcher from Griffith University. The author has contributed to research in topics: Adenosine & Adenosine receptor. The author has an hindex of 12, co-authored 19 publications. Previous affiliations of Laura Willems include James Cook University.
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Papers
Cardiac and coronary function in the Langendorff-perfused mouse heart model.
Melissa E. Reichelt,Melissa E. Reichelt,Laura Willems,Laura Willems,Benjamin A. Hack,Jason Nigel John Peart,John P. Headrick +6 more
TL;DR: Data indicate that attention to age (and sex) of mice will reduce variability in contractile function and ischaemic responses, and the model is applicable to the study of vascular reactivity, providing large responses and excellent reproducibility.
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Genetic Deletion of the A1 Adenosine Receptor Limits Myocardial Ischemic Tolerance
Melissa E. Reichelt,Laura Willems,Jose G. Molina,Chun Xiao Sun,Janci C. Noble,Kevin J. Ashton,Jurgen Schnermann,Michael R. Blackburn,John P. Headrick +8 more
TL;DR: Data indicate the function of intrinsically activated A1ARs appears primarily to be enhancement of postischemic contractility and limitation of cell death, and the first demonstrating global deletion of the A1 AR limits intrinsic myocardial resistance to ischemia.
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Receptor and non-receptor-dependent mechanisms of cardioprotection with adenosine
TL;DR: Protective effects of adenosine during ischemia-reperfusion were resistant to 5-HD and chelerythrine and only abolished when inhibitors were coinfused with iodotubercidin.
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Effects of aging and ischemia on adenosine receptor transcription in mouse myocardium.
TL;DR: Age- and ischemia-dependent changes in adenosine receptor transcript levels (Adora) for the A(1), A(2A), A (2B), and A(3) receptor subtypes in mouse myocardium are investigated to demonstrate selective modulation of cardioprotective adenoine receptor transcription by both aging and isChemia.
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Age-associated shifts in cardiac gene transcription and transcriptional responses to ischemic stress.
TL;DR: Age-associated up-regulation of transcripts involved in cell death, oxygen transport and metabolism in normoxic hearts is identified, and aging is associated with shifts in cardiovascular gene expression consistent with the phenotypic features of older hearts.
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