Laura Trovò
Katholieke Universiteit Leuven
9 Papers
7 Citations
Laura Trovò is an academic researcher from Katholieke Universiteit Leuven. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 5, co-authored 6 publications. Previous affiliations of Laura Trovò include Catholic University of Leuven.
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Papers
Improvement of biochemical and behavioral defects in the Niemann-Pick type A mouse by intraventricular infusion of MARCKS
TL;DR: It is reported here that high sphingomyelin levels in mutant neurons lead to low synaptic levels of phosphoinositide PI(4,5)P2 and reduced activity of its hydrolyzing phosphatase PLCγ, which are key players in synaptic plasticity events.
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Glutathione in the nucleus accumbens regulates motivation to exert reward-incentivized effort
Ioannis Zalachoras,Eva Ramos-Fernández,Fiona Hollis,Laura Trovò,João Rodrigues,Alina Strasser,Olivia Zanoletti,Pascal Steiner,Nicolas Preitner,Lijing Xin,Simone Astori,Carmen Sandi +11 more
TL;DR: Data indicate a close association between accumbal GSH levels and individual’s capacity to exert reward-incentivized effort over time and suggest that improvement of Accumbal antioxidant function may be a feasible approach to boost motivation.
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Regulation of tyrosine kinase B activity by the Cyp46/cholesterol loss pathway in mature hippocampal neurons: relevance for neuronal survival under stress and in aging.
Alejandro O. Sodero,Laura Trovò,Francesca Iannilli,Paul P. Van Veldhoven,Carlos G. Dotti,Mauricio G. Martin +5 more
TL;DR: In this paper, it was shown that the brain is better suited to fight against the death signals generated from reactive oxygen species than against loss-of-function stimuli, indicating that the aged brain is more robust to reactive oxygen than against the loss of function stimuli.
Targeting the TCA cycle can ameliorate widespread axonal energy deficiency in neuroinflammatory lesions
Yi-Heng Tai,Daniel Engels,Giuseppe Locatelli,Caroline Fecher,Delphine Theodorou,Stephan A. Müller,Simon Licht-Mayer,Mario Kreutzfeldt,Ingrid Wagner,Natália Prudente de Mello,Laura Trovò,Arek Kendirli,Almir Aljovic,Michael O. Breckwoldt,Ronald Naumann,Florence M. Bareyre,Fabiana Perocchi,Don H Mahad,Doron Merkler,Stefan F. Lichtenthaler,Martin Kerschensteiner,Thomas Misgeld +21 more
TL;DR: In this article , the authors combine cell type-specific mitochondrial proteomics with in vivo biosensor imaging to dissect how inflammation alters the molecular composition and functional capacity of neuronal mitochondria.
Sphingomyelin upregulation in mature neurons contributes to TrkB activity by Rac1 endocytosis.
TL;DR: Developmental upregulation of SM is revealed as an important mechanism for sustaining TrkB activity in the mature nervous system, in addition to the presence of brain-derived neurotrophic factor (BDNF).