Laura Schaedel
University of Grenoble
15 Papers
51 Citations
Laura Schaedel is an academic researcher from University of Grenoble. The author has contributed to research in topics: Microtubule & Tubulin. The author has an hindex of 9, co-authored 13 publications. Previous affiliations of Laura Schaedel include Centre national de la recherche scientifique & University of Barcelona.
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Papers
Microtubules acquire resistance from mechanical breakage through intralumenal acetylation
Zhenjie Xu,Laura Schaedel,Didier Portran,Andrea Aguilar,Jérémie Gaillard,M. Peter Marinkovich,M. Peter Marinkovich,Manuel Théry,Manuel Théry,Maxence V. Nachury +9 more
TL;DR: It is found that tubulin acetylation is required for the mechanical stabilization of long-lived microtubules in cells and increases mechanical resilience to ensure the persistence ofLong-livedmicrotubules.
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Tubulin acetylation protects long-lived microtubules against mechanical ageing.
TL;DR: FRET-based assays that report on the lateral interactions between protofilaments are developed and find that αK40 acetylation directly weakens inter-protofilament interactions, which protects long-lived microtubules from mechanical ageing and enhances flexibility and resilience against repeated mechanical stresses.
Self-repair promotes microtubule rescue
Charlotte Aumeier,Laura Schaedel,Jérémie Gaillard,Karin John,Laurent Blanchoin,Laurent Blanchoin,Manuel Théry,Manuel Théry +7 more
TL;DR: By securing damaged microtubules growth, the self-repair process supports a mechanosensitive growth by specifically promoting microtubule assembly in regions where they are subjected to physical constraints.
Lattice defects induce microtubule self-renewal
Laura Schaedel,Sarah Triclin,Denis Chrétien,Ariane Abrieu,Charlotte Aumeier,Jérémie Gaillard,Laurent Blanchoin,Laurent Blanchoin,Manuel Théry,Manuel Théry,Karin John +10 more
TL;DR: It is reported that thermal forces are sufficient to remodel the microtubule shaft, despite its apparent stability, and it is suggested that dimers can spontaneously leave and be incorporated into the lattice at structural defects.
CLASP Mediates Microtubule Repair by Restricting Lattice Damage and Regulating Tubulin Incorporation.
Amol Aher,Dipti Rai,Laura Schaedel,Jérémie Gaillard,Karin John,Qingyang Liu,Maarten Altelaar,Laurent Blanchoin,Laurent Blanchoin,Manuel Théry,Manuel Théry,Anna Akhmanova +11 more
TL;DR: In vitro reconstitution assays combined with laser microsurgery and microfluidics were used to show that CLASP2α indeed stimulates microtubule lattice repair and promotes tubulin incorporation into damaged lattice sites, thereby restoring microtubules integrity.
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