Laura Ryder
6 Papers
Laura Ryder is an academic researcher. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 1, co-authored 2 publications.
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Papers
Ribosome stalling is a signal for metabolic regulation by the ribotoxic stress response
Goda Snieckute,Aitana Victoria Genzor,Anna Vind,Laura Ryder,Mark Stoneley,Sébastien Chamois,René Dreos,Cathrine Nordgaard,Frederike Sass,Melanie Blasius,Aida Rodríguez López,Sólveig H. Brynjólfsdóttir,Kasper L. Andersen,Anne E. Willis,Lisa B. Frankel,Steen Seier Poulsen,David Gatfield,Zachary Gerhart-Hines,Christoffer Clemmensen,Simon Bekker-Jensen +19 more
TL;DR: In this article , it was shown that stalling of ribosomes is sufficient to activate MAP3K ZAKα, which leads to activation of p38 and JNK kinases.
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ROS-induced ribosome impairment underlies ZAKα-mediated metabolic decline in obesity and aging
Goda Snieckute,Laura Ryder,Anna Vind,Zhenzhen Wu,Frederic S Arendrup,Mark Stoneley,Sébastien Chamois,Ana Martinez-Val,Marion Leleu,René Dreos,Alexander Russell,David Michael Gay,Aitana Victoria Genzor,Béatrice S.-Y. Choi,Astrid L. Basse,Frederike Sass,Morten Dall,Lucile Chantal Marie Dollet,Melanie Blasius,Anne E Willis,Anders H Lund,Jonas T. Treebak,Jesper V. Olsen,Steen Seier Poulsen,Mary Elizabeth Pownall,Benjamin Anderschou Holbech Jensen,Christoffer Clemmensen,Zach Gerhart-Hines,David Gatfield,Simon Bekker-Jensen +29 more
TL;DR: It is shown that reactive oxygen species (ROS)–generating agents trigger ribosomal impairment and ZAKα activation, and that ROS activates the RSR in cellular models, associated with both stalling and collision of ribosomes.
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Nitric oxide-induced ribosome collision activates ribosomal surveillance mechanisms
Laura Ryder,Frederic S Arendrup,José Francisco Martínez,Goda Snieckute,Chiara Pecorari,R. A. Shah,Anders H. Lund,Melanie Blasius,Simon Bekker-Jensen +8 more
TL;DR: It is shown that a burst of the cellular signaling molecule nitric oxide reduces translational activity and causes ribosome collision in human cell lines and is associated with ZNF598-mediated ubiquitination of the ribosomal protein RPS10 and GCN2-mediated activation of the integrated stress response, which are well-described responses to the collision of ribosomes.
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Mechanisms underlying sensing of cellular stress signals by mammalian MAP3 kinases.
Kelly Mordente,Laura Ryder,Simon Bekker-Jensen +2 more
TL;DR: The existing knowledge of how individual members of the large and diverse group of MAP3Ks sense specific stress signals through largely non-redundant mechanisms is reviewed and the large knowledge gaps in assigning function and stress signals for individual MAP3K family members are emphasized.
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