Laura J. den Hartigh
University of Washington
35 Papers
66 Citations
Laura J. den Hartigh is an academic researcher from University of Washington. The author has contributed to research in topics: Adipose tissue & Internal medicine. The author has an hindex of 15, co-authored 27 publications. Previous affiliations of Laura J. den Hartigh include University of California, Davis.
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Papers
Adipose Tissue Distribution, Inflammation and Its Metabolic Consequences, Including Diabetes and Cardiovascular Disease.
Alan Chait,Laura J. den Hartigh +1 more
TL;DR: The mechanisms by which dysfunctional adipose tissue simultaneously promote T2DM and CVD, focusing on adipose tissues depot-specific adipokines, inflammatory profiles, and metabolism, will be the focus of this review.
Conjugated linoleic acid effects on cancer, obesity, and atherosclerosis: A review of pre-clinical and human trials with current perspectives
TL;DR: The potential mechanisms for the many integrative physiological effects of CLA supplementation will be discussed in detail, including an introduction to the gut microbiota as a potential mediator of CLA effects on obesity and atherosclerosis.
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Adipocyte-Specific Deficiency of NADPH Oxidase 4 Delays the Onset of Insulin Resistance and Attenuates Adipose Tissue Inflammation in Obesity.
Laura J. den Hartigh,Mohamed Omer,Leela Goodspeed,Shari Wang,Tomasz Wietecha,Kevin D. O'Brien,Chang Yeop Han +6 more
TL;DR: Findings imply that NOX4-derived ROS may play a role in the onset of insulin resistance and adipose tissue inflammation, and therapeutics targeting NOx4-mediated ROS production could be effective in preventing obesity-associated conditions, such as insulin resistance.
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Fatty acids from very low-density lipoprotein lipolysis products induce lipid droplet accumulation in human monocytes
Laura J. den Hartigh,Jaime E. Connolly-Rohrbach,Samantha Fore,Thomas R Huser,John C. Rutledge +4 more
TL;DR: In this paper, the authors examined post-prandial monocyte activation in more detail, and found that lipolysis products generated from post-andial VLDL induce the formation of lipidfilled droplets within cultured THP-1 monocytes, characterized by coherent antistokes Raman spectroscopy.
Serum amyloid A3 is a high density lipoprotein-associated acute-phase protein
Lisa R. Tannock,Maria C. de Beer,Ailing Ji,Preetha Shridas,Victoria P. Noffsinger,Laura J. den Hartigh,Alan Chait,Frederick C. de Beer,Nancy R. Webb +8 more
TL;DR: SAA3 is a major hepatic acute-phase SAA in mice that may produce systemic effects during inflammation, and appears to be more loosely associated with HDL, resulting in lipid-poor/free SAA3.
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