Laura Gardner
Indiana University
13 Papers
41 Citations
Laura Gardner is an academic researcher from Indiana University. The author has contributed to research in topics: Breast cancer & Medicine. The author has an hindex of 6, co-authored 7 publications. Previous affiliations of Laura Gardner include Indiana University – Purdue University Indianapolis.
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Papers
Genome-Wide Association Studies for Taxane-Induced Peripheral Neuropathy in ECOG-5103 and ECOG-1199
Bryan P. Schneider,Lang Li,Milan Radovich,Fei Shen,Kathy D. Miller,David A. Flockhart,Guanglong Jiang,Gail H. Vance,Laura Gardner,Matteo Vatta,Shaochun Bai,Dongbing Lai,Daniel L. Koller,Fengmin Zhao,Anne O'Neill,Mary Lou Smith,Elda Railey,Carol B. White,Ann H. Partridge,Joseph A. Sparano,Nancy E. Davidson,Tatiana Foroud,George W. Sledge +22 more
TL;DR: Genetically determined AA race represents the most significant predictor of TIPN, and SNP rs3125923 represents a validated SNP to predict grade 3-4 TIPn.
136
Charcot-Marie-Tooth gene, SBF2, associated with taxane-induced peripheral neuropathy in African Americans.
Bryan P. Schneider,Dongbing Lai,Fei Shen,Guanglong Jiang,Milan Radovich,Lang Li,Laura Gardner,Kathy D. Miller,Anne O'Neill,Joseph A. Sparano,Gloria Xue,Tatiana Foroud,George W. Sledge +12 more
TL;DR: Rare variants in SBF2, a CMT gene, predict an increased risk of TIPN in AA patients receiving paclitaxel, a adjuvant, randomized phase III breast cancer trial.
Impact of Genetic Ancestry on Outcomes in ECOG-ACRIN-5103
Bryan P. Schneider,Fei Shen,Guanglong Jiang,Anne O'Neill,Milan Radovich,Lang Li,Laura Gardner,Dongbing Lai,Tatiana Foroud,Joseph A. Sparano,George W. Sledge,Kathy D. Miller +11 more
- 21 Aug 2017
TL;DR: This paper evaluated the impact of genetically determined ancestry on disparity in efficacy and therapy-induced toxicity for patients with breast cancer in the context of a randomized, phase III adjuvant trial.
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The impact of SBF2 on taxane-induced peripheral neuropathy.
Geneva M. Cunningham,Fei Shen,Xi Wu,Erica Cantor,Laura Gardner,Santosh Philips,Guanglong Jiang,Casey Bales,Zhiyong Tan,Yunlong Liu,Jun Wang,Jill C. Fehrenbacher,Bryan P. Schneider +12 more
TL;DR: Ex vivo support for the impact of SBF2 on the development of TIPN is provided and candidate genes involved in the exacerbation of paclitaxel-induced phenotypes accompanyingSBF2 knockdown are revealed.
A non-coding GWAS variant impacts anthracycline-induced cardiotoxic phenotypes in human iPSC-derived cardiomyocytes
Xi Wu,Fei Shen,Guanglong Jiang,Gloria Xue,Santosh Philips,Laura Gardner,Geneva M. Cunningham,Casey Bales,Erica Cantor,Bryan P. Schneider +9 more
TL;DR: In this paper , a germline single nucleotide polymorphism, rs28714259, associated with an increased risk of anthracycline-induced heart failure was identified and validated using HiPSC-derived cardiomyocyte cell lines with either intrinsic polymorphism or CRISPR-Cas9-mediated deletion of rs287 14259 locus.