Laura E. Blue
Amgen
9 Papers
8 Citations
Laura E. Blue is an academic researcher from Amgen. The author has contributed to research in topics: Chemistry & Computer science. The author has an hindex of 5, co-authored 6 publications. Previous affiliations of Laura E. Blue include University of North Carolina at Chapel Hill.
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Papers
Morphology and separation efficiency of low-aspect-ratio capillary ultrahigh pressure liquid chromatography columns.
TL;DR: This study derives a quantitative relationship between the bed morphology and the chromatographic separation efficiency of capillary columns packed with sub-2 μm particles, covering capillary inner diameters from 10 to 75 μm.
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Separation and quantitation of eight isomers in a molecule with three stereogenic centers by normal phase liquid chromatography.
Nilesh Joshi,Balaji Dhamarlapati,Athimoolam Pillai,Justine Paulose,Jessica Tan,Laura E. Blue,Jason S. Tedrow,Bob Farrell +7 more
TL;DR: The newly developed normal phase liquid chromatography method was developed for the separation and detection of eight stereoisomers of the key intermediate, CORE + OMe, having three chiral centers and used as the quality control method for chiral purity of the desired compound.
8
State-of-the-art and emerging trends in analytical approaches to pharmaceutical-product commercialization.
Laura E. Blue,Xiaoyang Guan,Marisa K. Joubert,Scott Kuhns,Stephanie Moore,David J. Semin,Mats Wikström,Jette Wypych,Chetan T. Goudar +8 more
TL;DR: The Product Quality Attribute Assessment (PQAA) and Quality Target Product Profile (QTPP) frameworks help catalog and translate molecular understanding to process and product-design targets, thereby enabling reliable manufacturing of high-quality product as mentioned in this paper .
2
One-Dimensional Simultaneous Achiral and Chiral Analysis
Laura E. Blue
- 01 Aug 2022
TL;DR: In this article , a mixed-mode column that can provide both achiral and chiral resolution in one-dimensional (1D) would significantly improve impurity profile understanding and reduce testing workload.
1.1 μm superficially porous particles for liquid chromatography. Part I: synthesis and particle structure characterization.
Laura E. Blue,James W. Jorgenson +1 more
TL;DR: In this study, the synthesis of smaller diameter superficially porous particles was investigated, however, synthesis parameters previously reported were rendered unsuitable due to particle agglomeration, non-uniform coating, and porous layer disintegration.