Laura Cano
University of Edinburgh
4 Papers
12 Citations
Laura Cano is an academic researcher from University of Edinburgh. The author has contributed to research in topics: Synonymous substitution & Selection (genetic algorithm). The author has an hindex of 3, co-authored 4 publications.
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Papers
Evidence for strong mutation bias towards, and selection against, U content in SARS-CoV-2: implications for vaccine design.
Alan M. Rice,Atahualpa Castillo Morales,Alexander T Ho,Christine Mordstein,Christine Mordstein,Stephanie Mühlhausen,Semir Watson,Laura Cano,Bethan Young,Bethan Young,Grzegorz Kudla,Laurence D. Hurst +11 more
TL;DR: An evolutionarily informed approach to attenuation is proposed that, unusually, seeks to increase usage of the already most common synonymous codons in SARS-CoV-2 genes.
Evidence for strong mutation bias towards, and selection against, T/U content in SARS-CoV2: implications for attenuated vaccine design.
Alan M. Rice,Atahualpa Castillo Morales,Alexander T Ho,Christine Mordstein,Christine Mordstein,Stefanie Mühlhausen,Samir F Watson,Laura Cano,Bethan Young,Bethan Young,Grzegorz Kudla,Laurence D. Hurst +11 more
TL;DR: An evolutionarily informed gene-bespoke approach to attenuation that, unusually, seeks to increase usage of the already most common synonymous codons in relation to SARS-CoV2 genes.
Transcription, mRNA export and immune evasion shape the codon usage of viruses
Christine Mordstein,Laura Cano,Atahualpa Castillo Morales,Bethan Young,Bethan Young,Alexander T Ho,Alan M. Rice,Michael Liss,Laurence D. Hurst,Grzegorz Kudla +9 more
TL;DR: This paper analyzed the patterns of codon usage in 1,520 vertebrate-infecting viruses, focusing on parameters known to be under selection and associated with gene regulation, and found that GC content, dinucleotide content, and splicing and m6A modification-related sequence motifs are associated with the type of genetic material (DNA or RNA), strandedness, and replication compartment of viruses.
Causes and consequences of purifying selection on SARS-CoV-2.
Atahualpa Castillo Morales,Alan M. Rice,Alexander T Ho,Christine Mordstein,Christine Mordstein,Christine Mordstein,Stefanie Mühlhausen,Samir F Watson,Laura Cano,Bethan Young,Bethan Young,Grzegorz Kudla,Laurence D. Hurst +12 more
TL;DR: In this article, it was shown that the SARS-CoV-2 mutation rate is at least 49-67% higher than would be estimated based on the rate of appearance of variants in sampled genomes.