Laura Bailey
Scottish National Blood Transfusion Service
5 Papers
46 Citations
Laura Bailey is an academic researcher from Scottish National Blood Transfusion Service. The author has contributed to research in topics: Cell therapy & Internal medicine. The author has an hindex of 4, co-authored 5 publications.
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Papers
Safety profile of autologous macrophage therapy for liver cirrhosis.
Francesca Moroni,Benjamin J. Dwyer,Catriona Graham,Chloe Pass,Laura Bailey,Lisa Ritchie,Donna Mitchell,Alison Glover,Audrey Laurie,Stuart Doig,Emily Hargreaves,Alasdair R. Fraser,Marc Turner,John D.M. Campbell,Neil W. A. McGowan,Jacqueline Barry,Joanna Moore,Peter C. Hayes,Diana Julie Leeming,Mette Juul Nielsen,Kishwar Musa,Jonathan A. Fallowfield,Stuart J. Forbes +22 more
TL;DR: A first-in-human, phase 1 dose-escalation trial demonstrates the safety and feasibility of autologous macrophage therapy in adults with liver cirrhosis and provides a rationale for efficacy studies in cir rhosis and other fibrotic diseases.
Development, functional characterization and validation of methodology for GMP-compliant manufacture of phagocytic macrophages: A novel cellular therapeutic for liver cirrhosis.
Alasdair R. Fraser,Chloe Pass,Paul Burgoyne,Anne P.M. Atkinson,Laura Bailey,Audrey Laurie,Neil W. A. McGowan,Akib Hamid,Joanna Moore,Benjamin J. Dwyer,Marc Turner,Marc Turner,Stuart J. Forbes,John D. M. Campbell,John D. M. Campbell +14 more
TL;DR: This is the first report of validation of a large-scale, fully Good Manufacturing Practice–compliant, autologous macrophage cell therapy product for the potential treatment of cirrhosis, and shows that the cell product in excipient is remarkably robust, consistently passing the viability and phenotypic release criteria up to 48 hours after harvest.
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Use of the BacT/Alert System for Rapid Detection of Microbial Contamination in a Pilot Study Using Pancreatic Islet Cell Products
TL;DR: This pilot study presents the BacT/Alert System as an alternative to manual testing to provide more rapid and sensitive sterility results for islet cell products.
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Phenotypic and functional characterization of macrophages with therapeutic potential generated from human cirrhotic monocytes in a cohort study
Joanna Moore,Alison C. MacKinnon,Dvina Wojtacha,Caroline Pope,Alasdair R. Fraser,Paul Burgoyne,Laura Bailey,Chloe Pass,Anne P.M. Atkinson,Neil W. A. McGowan,Lynn Manson,Mark L. Turner,John D.M. Campbell,Stuart J. Forbes +13 more
TL;DR: Macrophages can be differentiated from cirrhotic patients' apheresis-derived CD14 monocytes and develop the same pro-resolution phenotype as control macrophages, indicating their suitability for clinical therapy.
Pancreas-derived mesenchymal stromal cells share immune response-modulating and angiogenic potential with bone marrow mesenchymal stromal cells and can be grown to therapeutic scale under Good Manufacturing Practice conditions.
Kayleigh L. Thirlwell,Kayleigh L. Thirlwell,David Colligan,Joanne C. Mountford,Kay Samuel,Laura Bailey,Nerea Cuesta-Gomez,Kay Hewit,Kay Hewit,Christopher Kelly,Christopher C. West,Neil W. A. McGowan,John Casey,Gerard J. Graham,Marc Turner,Shareen Forbes,John M. Campbell,John M. Campbell +17 more
TL;DR: LPIs express patterns of chemokines and pro-regenerative factors similar to those of BM MSCs and, importantly, are equally able to attract immune cells in vitro and in vivo and suppress T-cell proliferation in vitro.