211 Papers
3K Citations
Laszlo Tora is an academic researcher from French Institute of Health and Medical Research. The author has contributed to research in topics: Transcription factor II D & RNA polymerase II. The author has an hindex of 73, co-authored 204 publications. Previous affiliations of Laszlo Tora include Centre national de la recherche scientifique & Tokyo University of Agriculture.
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Papers
The N-terminal part of TIF1, a putative mediator of the ligand-dependent activation function (AF-2) of nuclear receptors, is fused to B-raf in the oncogenic protein T18.
B Le Douarin,C. Zechel,Jean-Marie Garnier,Yves Lutz,Laszlo Tora,P. Pierrat,David M. Heery,Hinrich Gronemeyer,Pierre Chambon,Régine Losson +9 more
TL;DR: It is proposed that TIF1, which contains several conserved domains found in transcriptional regulatory proteins, is a mediator of ligand‐dependent AF‐2, and the N‐terminal moiety is fused to B‐raf in the mouse oncoprotein T18.
660
Collisions between Replication and Transcription Complexes Cause Common Fragile Site Instability at the Longest Human Genes
TL;DR: The results show that, on the longest human genes, collisions of the transcription machinery with a replication fork are inevitable, creating R-loops and consequent CFS formation, and functional replication machinery needs to be involved in the resolution of conflicts between transcription and replication machineries to ensure genomic stability.
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H3K9 and H3K14 acetylation co-occur at many gene regulatory elements, while H3K14ac marks a subset of inactive inducible promoters in mouse embryonic stem cells
Krishanpal Karmodiya,Arnaud R Krebs,Arnaud R Krebs,Mustapha Oulad-Abdelghani,Hiroshi Kimura,Laszlo Tora +5 more
TL;DR: It is suggested that chromatin modifications, such as H3K9ac and H2K14ac, are part of the active promoter state, are present over bivalent promoters and active enhancers and that the extent of H3 k9 and H3k14 acetylation could be driven by cis regulatory elements such as CpG content at promoters.
Functional interference between hypoxia and dioxin signal transduction pathways: competition for recruitment of the Arnt transcription factor.
Katarina Gradin,Jacqueline McGuire,Roland H. Wenger,Ivica Kvietikova,M L fhitelaw,Rune Toftgård,Laszlo Tora,Max Gassmann,Lorenz Poellinger +8 more
TL;DR: It is demonstrated that HIF-1 alpha required Arnt for DNA binding in vitro and functional activity in vivo, and observed that Hif-1alpha was associated with the molecular chaperone hsp90, possibly by binding an as yet unknown class of ligands.
477
seqMINER: an integrated ChIP-seq data interpretation platform
Tao Ye,Arnaud R Krebs,Mohamed Amin Choukrallah,Céline Keime,Frédéric Plewniak,Irwin Davidson,Laszlo Tora +6 more
TL;DR: An integrated portable ChIP-seq data interpretation platform called seqMINER, with optimized performances for efficient handling of multiple genome-wide datasets, which can handle the biological complexity of most experimental situations and proposes methods to the user for data classification according to the analysed features.