László Szalay
University of Alabama at Birmingham
11 Papers
121 Citations
László Szalay is an academic researcher from University of Alabama at Birmingham. The author has contributed to research in topics: Androstenediol & Medicine. The author has an hindex of 11, co-authored 11 publications. Previous affiliations of László Szalay include University of Alabama.
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Papers
Androstenediol ameliorates alterations in immune cells cytokine production capacity in a two-hit model of trauma-hemorrhage and sepsis.
Takao Suzuki,Tomoharu Shimizu,László Szalay,Mashkoor A. Choudhry,Loring W. Rue,Kirby I. Bland,Irshad H. Chaudry +6 more
TL;DR: Since androstenediol administration following T-H attenuated cytokine production and reduced mortality in a double-hit model of T- H and sepsis, this agent appears to be a novel and useful adjunct for maintaining the immune cell functions following T -H and for decreasing the mortality rate from subsequent susceptibility to sepsi.
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Androstenediol administration after trauma-hemorrhage attenuates inflammatory response, reduces organ damage, and improves survival following sepsis
László Szalay,Tomoharu Shimizu,Takao Suzuki,Ya-Ching Hsieh,Mashkoor A. Choudhry,Martin G. Schwacha,Kirby I. Bland,Irshad H. Chaudry,Irshad H. Chaudry +8 more
TL;DR: Since adiol administration suppresses proinflammatory cytokines, reduces liver damage, and decreases mortality after the combined insult of T-H and sepsis, this agent appears to be a novel adjunct to fluid resuscitation for decreasing T- H-induced septic complications and mortality.
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17β-Estradiol modulates vasoconstriction induced by endothelin-1 following trauma-hemorrhage
Zheng F. Ba,Ailing Lu,Tomoharu Shimizu,László Szalay,Martin G. Schwacha,Loring W. Rue,Kirby I. Bland,Irshad H. Chaudry +7 more
TL;DR: E(2) administration attenuates ET-1-induced vasoconstriction following trauma-hemorrhage via an ER-beta-mediated pathway that is dependent on endothelium-derived NO synthesis.
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Mechanism of salutary effects of androstenediol on hepatic function after trauma-hemorrhage: role of endothelial and inducible nitric oxide synthase.
Tomoharu Shimizu,László Szalay,Mashkoor A. Choudhry,Martin G. Schwacha,Loring W. Rue,Kirby I. Bland,Irshad H. Chaudry +6 more
TL;DR: Improved hepatic perfusion by androstenediol after T-H is likely due to a decrease in endothelin-1 and induction of eNOS, and the decrease in hepatic damage after and Frostenediol administration is likely related to liver iNOS downregulation.
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A Role of PPAR-γ in Androstenediol-Mediated Salutary Effects on Cardiac Function Following Trauma-Hemorrhage
Tomoharu Shimizu,László Szalay,Ya-Ching Hsieh,Takao Suzuki,Mashkoor A. Choudhry,Kirby I. Bland,Irshad H. Chaudry +6 more
TL;DR: The androstenediol-mediated salutary effects on cardiac function following T-H appear to be mediated at least in part via PPAR-γ activation, which down-regulates IL-6 and iNOS gene expression in the heart.
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