László Sámi
University of Debrecen
9 Papers
45 Citations
László Sámi is an academic researcher from University of Debrecen. The author has contributed to research in topics: Penicillium chrysogenum & Autolysis (biology). The author has an hindex of 6, co-authored 9 publications.
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Papers
•Journal Article
Autolysis of Penicillium chrysogenum-A Holistic Approach
TL;DR: The autolysis of 13-lactam producing fungus, Penicillium chrysogenum shares some similarities with the apoptosis of higher eukaryotes, but no firm correlation was found between the GSHIglutathione disulphide redox status, the intracellular ROS levels and the observed morphological and physiological characteristics of the cells.
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Co-ordination of the nitrate and nitrite assimilation, the glutathione and free radical metabolisms, and the pentose phosphate pathway in Penicillium chrysogenum
TL;DR: The specific glutathione reductase and glucose‐6‐phosphate dehydrogenase activities increased significantly in Penicillium chrysogenum grown on glucose in the presence of either nitrate or nitrite, which kept the intracellular peroxide levels low and prevented the onset of any glutathion/glutathione disulphide redox imbalances.
14
Searching for new-type antifungal drugs (An outline for possible new strategies)
TL;DR: Three different strategies are presented and evaluated to find new-type antifungal drugs and their targets and it is found that chitinase inhibitors seem to hinder the cell separation of yeasts and the fragmentation of filamentous fungi quite effectively and, hence, they may be implicated in future therapies of systemic mycoses.
Does the detoxification of penicillin side-chain precursors depend on microsomal monooxygenase and glutathione S-transferase in Penicillium chrysogenum?
TL;DR: A microsomal monooxygenase (causing possible release of epoxide intermediates) and mGST‐dependent detoxification pathway may exist for the side‐chain precursors as an alternative tomicrosomal activation to acyl‐CoA and subsequent transfer to β‐lactam molecules.
8
The glutathione metabolism of the beta-lactam producer filamentous fungus Penicillium chrysogenum.
TL;DR: A promising way to keep the GSH pool selectively down under penicillin producing conditions is shown and the hypothesis that the formation of different kinds of penicillins would be an alternative to GSH-dependent detoxification processes in P. chrysogenum is challenged.