László Lázár
University of Debrecen
69 Papers
458 Citations
László Lázár is an academic researcher from University of Debrecen. The author has contributed to research in topics: Chemistry & Ring (chemistry). The author has an hindex of 18, co-authored 69 publications. Previous affiliations of László Lázár include Hungarian Academy of Sciences & University of Turku.
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Papers
Synthesis of S-linked glycoconjugates and S-disaccharides by thiol-ene coupling reaction of enoses.
TL;DR: Free-radical hydrothiolation of the endocyclic double bond of enoses is reported and Reaction between 2-acetoxy-D-glucal and a range of thiols including amino acid, peptide, glycosylThiols, and sugars with primary or secondary thiol functions gave S-linked α- glucoconjugates and S-disaccharides with full regio- and stereoselectivity.
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Systematic study on free radical hydrothiolation of unsaturated monosaccharide derivatives with exo- and endocyclic double bonds
László Lázár,Magdolna Csávás,Ádám Hadházi,Mihály Herczeg,Marietta Tóth,László Somsák,Terézia Barna,Pál Herczegh,Anikó Borbás +8 more
TL;DR: It is demonstrated that the endocyclic double bond of Neu5Ac-2-ene, bearing an electron-withdrawing substituent, shows sufficient reactivity in the photoinduced thiol-ene coupling reaction.
Novel Pyridazinone Inhibitors for Vascular Adhesion Protein- 1 (Vap-1): Old Target - New Inhibition Mode.
Eva Bligt-Lindén,Marjo Pihlavisto,István Szatmári,Zbyszek Otwinowski,David J. Smith,László Lázár,Ferenc Fülöp,Tiina A. Salminen +7 more
TL;DR: The synthesis, inhibitory activity, and molecular binding mode of novel pyridazinone inhibitors, which show specificity for VAP-1 over monoamine and diamine oxidases, are reported, proving the potency and specificity of these new inhibitors.
Thio-click approach to the synthesis of stable glycomimetics
László Lázár,Magdolna Csávás,Marietta Tóth,László Somsák,Anikó Borbás +4 more
- 01 Jun 2015
TL;DR: Carbon-sulfur-bridged glycomimetics were prepared by free radical hydrothiolation of the exocyclic double bond of unsaturated sugars with full stereoselectivity by reaction between benzoyl-substituted pyranoid-exoglycal and a range of thiols.
Synthesis and anticoagulant activity of bioisosteric sulfonic-Acid analogues of the antithrombin-binding pentasaccharide domain of heparin.
Mihály Herczeg,László Lázár,Zsuzsanna Bereczky,Katalin E. Kövér,István Timári,János Kappelmayer,András Lipták,Sándor Antus,Anikó Borbás +8 more
TL;DR: In vitro evaluation of the anticoagulant activity of these new sulfonic-acid derivatives revealed that the disulfonate analogue inhibited the blood-coagulation-proteinase factor Xa with outstanding efficacy; however, the introduction of the third sulfonate moiety resulted in a notable decrease in the anti-Xa activity.
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