Lasse D. Jensen
8 Papers
Lasse D. Jensen is an academic researcher. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 1, co-authored 6 publications.
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Papers
VEGF-B prevents excessive angiogenesis by inhibiting FGF2/FGFR1 pathway
Chun-Chaing Lee,Rongyuan Chen,G. Sun,Xialin Liu,Xianchai Lin,Changying He,Liying Xing,Lixian Liu,Lasse D. Jensen,Anil Kumar,Harald F. Langer,Xiangrong Ren,Jianing Zhang,Lijuan Huang,Xiangke Yin,JongKyong Kim,Juanhua Zhu,Guanqun Huang,Jiani Li,Weiwei Lu,Juanxi Liu,Jiaxin Hu,Qihang Sun,Weisi Lu,Lekun Fang,Shasha Wang,Haiqing Kuang,Yihan Zhang,Geng Tian,Jia Mi,Bibo Kang,Masashi Narazaki,Aaron Prodeus,Luc Schoonjans,David M. Ornitz,Jean Gariépy,Guy Eelen,Mieke Dewerchin,Yunlong Yang,Jingsong Ou,Antonio Mora,Jin Yao,Chen Zhao,Yizhi Liu,Peter Carmeliet,Yihai Cao,Xuri Li +46 more
TL;DR: This work reveals for the first time an unexpected and surprising function of VEGF-B as an endogenous inhibitor of angiogenesis by inhibiting the FGF2/FGFR1 pathway when the latter is abundantly expressed.
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Disruption of the Clock Component Bmal1 in Mice Promotes Cancer Metastasis through the PAI-1-TGF-β-myoCAF-Dependent Mechanism.
Jieyu Wu,Xu Jing,Qiqiao Du,Xiao-tong Sun,Juan Gao,Xingkang He,Kayoko Hosaka,Chen Zhao,Wei Tao,Garret A. FitzGerald,Yunlong Yang,Lasse D. Jensen,Yihai Cao +12 more
TL;DR: In this paper , the authors demonstrated that the disruption of the circadian rhythm by genetic deletion of mouse brain and muscle ARNT-like 1 (Bmal1) gene, coding for the key clock transcription factor, augments an exacerbated fibrotic phenotype in various tumors.
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Novel Zebrafish Patient-Derived Tumor Xenograft Methodology for Evaluating Efficacy of Immune-Stimulating BCG Therapy in Urinary Bladder Cancer
Saskia Kowald,Ylva Huge,Decky Tandiono,Zaheer Ali,Gabriela Vazquez-Rodriguez,Anna Erkstam,Anna Fahlgren,Amir Sherif,Yihai Cao,Lasse D. Jensen +9 more
TL;DR: In this article , Bacillus Calmette-Guérin (BCG) immunotherapy is the standard-of-care adjuvant therapy for non-muscle-invasive bladder cancer in patients at considerable risk of disease recurrence.
Dietary ketone body–escalated histone acetylation in megakaryocytes alleviates chemotherapy-induced thrombocytopenia
Sisi Xie,Chenyu Jiang,Meng Wu,Ying Ye,Biying Wu,Xiao-tong Sun,Xue Lv,Ruibo Chen,Wen Yu,Qi Sun,Yuting Wu,Rong-Liang Que,Huilan Li,Ling Yang,Wen Liu,Ji Zuo,Lasse D. Jensen,Guichun Huang,Yihai Cao,Yunlong Yang +19 more
TL;DR: Xie et al. as mentioned in this paper demonstrate that a ketogenic diet alleviates chemotherapy-induced thrombocytopenia in both animals and humans without causing thrombo-ocytosis, which is a severe complication in patients with cancer that can lead to impaired therapeutic outcome and survival.
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Loss of REP1 impacts choroidal melanogenesis in choroideremia
Hajrah Sakar,Dhani Tracey-White,Ahmed M Hagag,Thomas Burgoyne,Lasse D. Jensen,Malia M. Edwards,Mariya Moosajee +6 more
TL;DR: Pigmentary disruptions in CHM animal models reveal an important role for REP1 in melanogenesis, and drugs that improve melanin production represent a potential novel therapeutic avenue.
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