Lars Franken
University of Bonn
8 Papers
Lars Franken is an academic researcher from University of Bonn. The author has contributed to research in topics: CTL* & Acquired immune system. The author has an hindex of 7, co-authored 8 publications.
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Papers
Crosstalk between Sentinel and Helper Macrophages Permits Neutrophil Migration into Infected Uroepithelium
Marzena Schiwon,Christina Weisheit,Lars Franken,Sebastian Gutweiler,Akanksha Dixit,Catherine Meyer-Schwesinger,Judith Mira Pohl,Nicholas J. Maurice,Stephanie Thiebes,Kristina Lorenz,Thomas Quast,Martin Fuhrmann,Georg Baumgarten,Martin J. Lohse,Ghislain Opdenakker,Jürgen Bernhagen,R Bucala,Ulf Panzer,Waldemar Kolanus,Hermann Josef Gröne,Natalio Garbi,Wolfgang Kastenmüller,Percy A. Knolle,Christian Kurts,Daniel R. Engel +24 more
TL;DR: Findings identify helper macrophages and TNF as critical regulators in innate immunity against bacterial infections in epithelia, reminiscent of the licensing role of helper T cells in antiviral adaptive immunity.
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Macrophages: sentinels and regulators of the immune system
TL;DR: This review will give an overview about what the authors know of macrophage ontogeny and will discuss the influence of the macrophages lineage and location on their functional specialization.
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Splenic red pulp macrophages are intrinsically superparamagnetic and contaminate magnetic cell isolates.
Lars Franken,Marika Klein,Marina Spasova,Anna Elsukova,Ulf Wiedwald,Meike Welz,Percy A. Knolle,Michael Farle,Andreas Limmer,Christian Kurts +9 more
TL;DR: It is shown that splenic red pulp macrophages accumulate ferrimagnetic iron oxides that render them intrinsically superparamagnetic, and a simple additional magnetic separation step is described that substantially improves purity of magnetic cell isolates from the spleen.
Splenic Red Pulp Macrophages Cross-Prime Early Effector CTL That Provide Rapid Defense against Viral Infections.
Marika Enders,Lars Franken,Marie-Sophie Philipp,Nina Kessler,Ann-Kathrin Baumgart,Melanie Eichler,Emmanuel J. H. J. Wiertz,Natalio Garbi,Christian Kurts +8 more
TL;DR: RPM can contribute to antiviral immunity by generating a rapid CTL defense force that contains the virus until cDC1-induced CTL are available to eliminate it.
Chemokines: a new dendritic cell signal for T cell activation
TL;DR: Recent advances in understanding of DC licensing for cross-priming are discussed and implications for the temporal and spatial regulation underlying this process are discussed.