Larry L. Kestin
Beaumont Hospital
228 Papers
1.8K Citations
Larry L. Kestin is an academic researcher from Beaumont Hospital. The author has contributed to research in topics: Radiation therapy & Medicine. The author has an hindex of 63, co-authored 212 publications. Previous affiliations of Larry L. Kestin include Wayne State University.
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Papers
Comparison of dose-escalated, image-guided radiotherapy vs. dose-escalated, high-dose-rate brachytherapy boost in a modern cohort of intermediate-risk prostate cancer patients
Ovidiu Marina,Gary S. Gustafson,Larry L. Kestin,Donald Brabbins,Peter Y. Chen,Hong Ye,Alvaro Martinez,Michel Ghilezan,M. Wallace,Daniel J. Krauss +9 more
TL;DR: Improved biochemical control with HDR-B for patients with worse pretreatment characteristics suggests that a subgroup of intermediate-risk prostate cancer patients may benefit from dual-modality treatment.
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PSA bounce after prostate brachytherapy with or without neoadjuvant androgen deprivation.
Samuel McGrath,J. Vito Antonucci,Dwight L. Fitch,Michel Ghilezan,Gary S. Gustafson,Frank A. Vicini,Alvaro Martinez,Larry L. Kestin +7 more
TL;DR: Bounces >or=1.0 ng/ml are rare after brachytherapy with or without neoadjuvant AD, occurring in less than 10% of patients, but as PB amplitude increases, the BF rate increases.
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Percentage of Biopsy Cores Positive for Malignancy and Biochemical Failure Following Prostate Cancer Radiotherapy in 3,264 Men: Statistical Significance Without Predictive Performance
Scott Williams,Mark K. Buyyounouski,Tom Pickles,Larry L. Kestin,Alvaro Martinez,Alexandra L. Hanlon,Gillian M. Duchesne +6 more
TL;DR: Outcome models incorporating PPC show only minor additional ability to predict biochemical failure beyond those containing standard prognostic factors and the model's predictive ability assessed using the concordance index.
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Long-term patterns of in-breast failure in patients with early stage breast cancer treated with breast-conserving therapy: a molecular based clonality evaluation.
Samuel McGrath,J.V. Antonucci,Neal S. Goldstein,Michelle Wallace,Chris Mitchell,Inga S. Grills,Shruti Jolly,Larry L. Kestin,Frank A. Vicini +8 more
TL;DR: This analysis demonstrates the inaccuracy of clinically establishing the clonality of most IBTRs, and provides a reliable means of identifying patients who may benefit from aggressive systemic therapy at the time of IBTR and provide an accurate assessment of the efficacy of various forms of local therapy.
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Required target margins for image-guided lung SBRT: Assessment of target position intrafraction and correction residuals
Chirag Shah,Larry L. Kestin,Andrew Hope,Jean-Pierre Bissonnette,Matthias Guckenberger,Ying Xiao,Jan-Jakob Sonke,José Belderbos,Di Yan,Inga S. Grills +9 more
TL;DR: Weight, excursion, forced expiratory volume in the first second of expiration, diffusing capacity of the lung for carbon monoxide, and treatment time were found to be significant predictors of IFV-MTP greater than 2 mm and 5 mm.
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