Larry E. Morrison
4 Papers
20 Citations
Larry E. Morrison is an academic researcher. The author has contributed to research in topics: Chemistry & Fluorescence. The author has an hindex of 4, co-authored 4 publications.
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Papers
Sensitive fluorescence-based thermodynamic and kinetic measurements of DNA hybridization in solution
Larry E. Morrison,Lucy M. Stols +1 more
TL;DR: The fluorescence measurements provided a unique "label dilution" method for measuring dissociation rate constants of oligomers based upon the dynamic association and dissociation of complementary DNA strands at constant temperature, thereby reducing hybridization rates and eliminating the need for rapid mixing and measurement techniques.
273
Phase change enzyme immunoassay
TL;DR: In this article, an enzyme-linked immunoassay employing a partitioning chromophore was developed, which consisted of an aqueous phase and an immiscible organic solvent.
20
Time-resolved detection of energy transfer: theory and application to immunoassays.
TL;DR: Good agreement between the experimental data and theory was obtained following convolution of the theoretical fluorescence responses with the instrumental response of the fluorometer, and the ratios of the energy-transfer component to the laser-excited component were found to increase by 9- to 15-fold when the 20-ns delay was used in three series of immunoassays.
Solution-phase detection of polynucleotides using interacting fluorescent labels and competitive hybridization
TL;DR: DNA was assayed in a homogeneous format using DNA probes containing hybridization-sensitive labels that were able to detect unlabeled target DNA by competitive hybridization producing fluorescence signals which increased with increasing target DNA concentration.