Lansha Peng
University of Pittsburgh
2 Papers
Lansha Peng is an academic researcher from University of Pittsburgh. The author has contributed to research in topics: MHC class I & T cell. The author has an hindex of 2, co-authored 2 publications.
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Papers
Prolongation of cardiac allograft survival using dendritic cells treated with NF-κB decoy oligodeoxyribonucleotides
Nick Giannoukakis,C. Andrew Bonham,Shiguang Qian,Zhongyou Zhou,Lansha Peng,Jo Harnaha,Wei Li,Angus W. Thomson,John J. Fung,Paul D. Robbins,Lina Lu +10 more
TL;DR: It is demonstrated that double-stranded oligodeoxyribonucleotides containing binding sites for NF-kB (NF-kB ODN) are efficiently incorporated by bone marrow-derived DC and specifically inhibit NF-kb-dependent transcription of a reporter gene.
Marked Prolongation of Cardiac Allograft Survival by Dendritic Cells Genetically Engineered with NF-κB Oligodeoxyribonucleotide Decoys and Adenoviral Vectors Encoding CTLA4-Ig
C. Andrew Bonham,Lansha Peng,Xiaoyan Liang,Zongyou Chen,Lianfu Wang,Linlin Ma,Holger Hackstein,Paul D. Robbins,Angus W. Thomson,John J. Fung,Shiguang Qian,Lina Lu +11 more
TL;DR: Use of NF-κB antisense decoys in conjunction with rAd encoding a potent costimulation blocking agent offers promise for therapy of allograft rejection or autoimmune disease with minimization of systemic immunosuppression.