Lani F. Wu
University of California, San Francisco
96 Papers
382 Citations
Lani F. Wu is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: Biology & Medicine. The author has an hindex of 32, co-authored 74 publications. Previous affiliations of Lani F. Wu include University of Texas Southwestern Medical Center & Harvard University.
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Papers
Genome-scale identification of nucleosome positions in S. cerevisiae.
Guo-Cheng Yuan,Yuen-Jong Liu,Michael F. Dion,Michael D. Slack,Lani F. Wu,Steven J. Altschuler,Oliver J. Rando +6 more
TL;DR: The authors used a tiled microarray approach to identify at high resolution the translational positions of 2278 nucleosomes over 482 kilobases of Saccharomyces cerevisiae DNA.
1.2K
Cellular Heterogeneity: Do Differences Make a Difference?
Steven J. Altschuler,Lani F. Wu +1 more
TL;DR: Examples of when heterogeneity cannot be ignored are discussed and practical strategies for analyzing and interpreting cellular heterogeneity are described.
1.2K
Membrane tension maintains cell polarity by confining signals to the leading edge during neutrophil migration
Andrew R. Houk,Alexandra Jilkine,Cecile O. Mejean,Rostislav Boltyanskiy,Eric R. Dufresne,Sigurd Angenent,Steven J. Altschuler,Lani F. Wu,Orion D. Weiner +8 more
TL;DR: It is suggested that tension, rather than diffusible molecules generated or sequestered at the leading edge, is the dominant source of long-range inhibition that constrains the spread of the existing front and prevents the formation of secondary fronts.
600
Diverse drug-resistance mechanisms can emerge from drug-tolerant cancer persister cells.
Michael Ramirez,Michael Ramirez,Satwik Rajaram,Robert J. Steininger,Daria Osipchuk,Maike A. Roth,Leanna S. Morinishi,Louise Evans,Weiyue Ji,Chien Hsiang Hsu,Kevin Thurley,Shuguang Wei,Anwu Zhou,Prasad Koduru,Bruce A. Posner,Lani F. Wu,Lani F. Wu,Steven J. Altschuler,Steven J. Altschuler +18 more
TL;DR: The drug-tolerant persister state does not limit—and may even provide a latent reservoir of cells for—the emergence of heterogeneous drug-resistance mechanisms, including the most commonly observed clinical resistance mechanisms.
531
Experimental annotation of the human genome using microarray technology
Daniel D. Shoemaker,Eric E. Schadt,Christopher D. Armour,Yudong D. He,Philip W. Garrett-engele,Paul McDonagh,Patrick M. Loerch,Amy Leonardson,Pek Yee Lum,Guy Cavet,Lani F. Wu,Steven J. Altschuler,Seve Edwards,Jason R. King,J. S. Tsang,Greg Schimmack,Janell M. Schelter,J. Koch,Michael Ziman,Matthew J. Marton,B. Li,P. Cundiff,Thomas R. Ward,John C. Castle,M. Krolewski,Miriam Meyer,Mao Mao,Julja Burchard,Matthew J. Kidd,Hongyue Dai,John W. Phillips,Peter S. Linsley,Roland Stoughton,Stephen W. Scherer,M. S. Boguski +34 more
TL;DR: Using ‘exon’ and ‘tiling’ arrays fabricated by ink-jet oligonucleotide synthesis, an experimental approach is devised to validate and refine computational gene predictions and define full-length transcripts on the basis of co-regulated expression of their exons.