Lance M. Relland
Medical College of Wisconsin
6 Papers
Lance M. Relland is an academic researcher from Medical College of Wisconsin. The author has contributed to research in topics: Biology & Antigen. The author has an hindex of 6, co-authored 6 publications.
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Papers
Regulatory T cell development in the absence of functional Foxp3
Wen Lin,Dipica Haribhai,Lance M. Relland,Nga Truong,Marc R. J. Carlson,Calvin B. Williams,Talal A. Chatila +6 more
TL;DR: The results indicate that Treg cell effector function but not lineage commitment requires the expression of functional Foxp3 protein.
504
A requisite role for induced regulatory T cells in tolerance based on expanding antigen receptor diversity.
Dipica Haribhai,Jason B. Williams,Shuang Jia,Derek W. Nickerson,Erica G. Schmitt,Brandon Edwards,Jennifer Ziegelbauer,Maryam Yassai,Shun Hwa Li,Lance M. Relland,Petra Wise,A. W. Chen,Yu Qian Zheng,Pippa Simpson,Jack Gorski,Nita H. Salzman,Martin J. Hessner,Talal A. Chatila,Calvin B. Williams +18 more
TL;DR: In adoptive transfer immunotherapy of newborn Foxp3-deficient mice, iTreg cells are an essential nonredundant regulatory subset that supplements nTreg cells in part by expanding TCR diversity within regulatory responses.
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Regulatory T cells dynamically control the primary immune response to foreign antigen.
TL;DR: An inverse quantitative relationship between TR and conventional T cells that controls the magnitude of the primary immune response is defined and suggests degenerate TCR specificity enabling activation by a broad spectrum of Ags.
242
Affinity-based selection of regulatory T cells occurs independent of agonist-mediated induction of Foxp3 expression.
Lance M. Relland,Manoj K. Mishra,Dipica Haribhai,Brandon Edwards,Jennifer Ziegelbauer,Calvin B. Williams +5 more
TL;DR: It is demonstrated that the nT Reg TCR repertoire is shaped by affinity-based selection, similar to conventional T cells, and the effect of each ligand on the two populations is distinct, consistent with early nTreg cell lineage specification.
35
1,25-Dihydroxyvitamin D3 acts directly on the T lymphocyte vitamin D receptor to inhibit experimental autoimmune encephalomyelitis
TL;DR: It is found that hematopoietic cell VDR function was necessary for 1,25‐(OH)2D3 to inhibit EAE, and conditional targeting experiments showed that VDRfunction in T cells was necessary, supporting a model wherein 1, 25‐ (OH) 2D3 acts directly on pathogenic CD4+ T cells to inhibitEAE.