Lance Daharsh
University of Nebraska–Lincoln
10 Papers
6 Citations
Lance Daharsh is an academic researcher from University of Nebraska–Lincoln. The author has contributed to research in topics: Microbiome & Population. The author has an hindex of 3, co-authored 8 publications. Previous affiliations of Lance Daharsh include Iowa State University.
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Papers
Reference Transcriptomes of Porcine Peripheral Immune Cells Created Through Bulk and Single-Cell RNA Sequencing
Juber Herrera-Uribe,Jayne E. Wiarda,Jayne E. Wiarda,Jayne E. Wiarda,Sathesh K. Sivasankaran,Sathesh K. Sivasankaran,Lance Daharsh,Haibo Liu,Kristen A Byrne,Timothy P L Smith,Joan K. Lunney,Crystal L. Loving,Christopher K. Tuggle +12 more
TL;DR: Pigs are a valuable human biomedical model and an important protein source supporting global food security as mentioned in this paper, and the transcriptomes of peripheral blood immune cells in pigs were defined at the bulk cell-type and single cell levels.
A Double Humanized BLT-mice Model Featuring a Stable Human-Like Gut Microbiome and Human Immune System.
TL;DR: A protocol that does not require germ-free animals or gnotobiotic facilities to be developed and was stable in the double hu-BLT mice for the duration of the study up to 14.5 weeks post-transplant.
A DNA Vaccine Expressing Consensus Hemagglutinin-Esterase Fusion Protein Protected Guinea Pigs from Infection by Two Lineages of Influenza D Virus.
Yanmin Wan,Guobin Kang,Chithra C. Sreenivasan,Lance Daharsh,Junfeng Zhang,Wenjin Fan,Dan Wang,Hideaki Moriyama,Feng Li,Qingsheng Li +9 more
TL;DR: A DNA vaccine encoding the consensus hemagglutinin-esterase fusion (HEF) protein of two lineages of IDV (D/OK and D/660) is designed and tested and demonstrates for the first time that the consensus IDV HEF DNA vaccine can elicit complete protection against infection from two lineage IDV in the guinea pig model.
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Stable Engraftment of a Human Gut Bacterial Microbiome in Double Humanized BLT-mice
TL;DR: Double humanized mice with both a functional human immune system and stable human-like gut microbiome are created to study the complex in vivo relationships of the gut microbiome, immune system, and human disease in vivo.
Identification of Unequally Represented Founder Viruses Among Tissues in Very Early SIV Rectal Transmission.
Jian Chen,Yanqin Ren,Yanqin Ren,Lance Daharsh,Lu Liu,Guobin Kang,Qingsheng Li,Qiang Wei,Yanmin Wan,Yanmin Wan,Jianqing Xu +10 more
TL;DR: It is suggested that descending colon/jejunum might be more susceptible than rectum to SIV in the very early phase of infection, and host CG suppression may also contribute to the bottleneck selection during in vivo transmission.