Lan Yang
Xi'an Jiaotong University
17 Papers
16 Citations
Lan Yang is an academic researcher from Xi'an Jiaotong University. The author has contributed to research in topics: AMPK & PI3K/AKT/mTOR pathway. The author has an hindex of 10, co-authored 17 publications.
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Papers
Activation of AMPK inhibits PDGF-induced pulmonary arterial smooth muscle cells proliferation and its potential mechanisms
Yang Song,Yuanyuan Wu,Xiaofan Su,Yanting Zhu,Lu Liu,Yilin Pan,Bo Zhu,Lan Yang,Li Gao,Manxiang Li +9 more
TL;DR: The study suggests that the activation of AMPK negatively regulates mTOR activity to suppress PASMC proliferation and therefore has a potential value in the prevention and treatment of pulmonary hypertension by negatively modulating pulmonary vascular remodeling.
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Activation of AMPK Prevents Monocrotaline-Induced Extracellular Matrix Remodeling of Pulmonary Artery.
Shaojun Li,Dong Han,Yonghong Zhang,Xinming Xie,Rui Ke,Yanting Zhu,Lu Liu,Yang Song,Lan Yang,Manxiang Li +9 more
TL;DR: This study suggests that activation of AMPK benefits PAH by inhibiting ECM remodeling of pulmonary arteries and Enhancing AMPK activity might have potential value in clinical treatment of PAH.
Activation of AMPK α2 inhibits airway smooth muscle cells proliferation.
TL;DR: The study suggests that activation of AMPK, particularly AMPK α2, negatively regulates mTOR activity to suppress ASMCs proliferation and therefore has a potential value in the prevention and treatment of asthma by negatively modulating airway remodeling.
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Inhibition of ubiquitin proteasome function prevents monocrotaline-induced pulmonary arterial remodeling
Yanting Zhu,Yinxia Wu,Wenhua Shi,Jian Wang,Xin Yan,Qingting Wang,Ya Liu,Lan Yang,Li Gao,Manxiang Li +9 more
TL;DR: Inhibition of proteasome function ameliorates pulmonary arterial remodeling by suppressing UPS‐mediated PTEN degradation and subsequent inhibition of PI3K/Akt pathway, indicating that UPS might be a novel target for prevention of PAH.
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MicroRNA-27a/b mediates endothelin-1-induced PPARγ reduction and proliferation of pulmonary artery smooth muscle cells
Xinming Xie,Shaojun Li,Yanting Zhu,Lu Liu,Yilin Pan,Jian Wang,Wenhua Shi,Yang Song,Lan Yang,Li Gao,Weijin Zang,Manxiang Li +11 more
TL;DR: This study demonstrates thatET-1 stimulates miR-27a/b expression by activation of the NF-κB pathway, which in turn results in PPARγ reduction and contributes to ET-1-induced PASMC proliferation.
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