4 Papers
32 Citations
Lan Yang is an academic researcher from University of Southern California. The author has contributed to research in topics: Nuclear receptor coactivator 2 & Nuclear receptor coactivator 3. The author has an hindex of 4, co-authored 4 publications.
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Papers
An Additional Region of Coactivator GRIP1 Required for Interaction with the Hormone-binding Domains of a Subset of Nuclear Receptors
TL;DR: Another region of coactivator GRIP1 (amino acids 1011–1121), called the auxiliary NID (NIDaux), is required in vitro and in vivo for efficient interaction with a subset of NRs, including the glucocorticoid receptor (GR), androgen receptor, and retinoic acid receptor α.
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Distinct LIM domains of Hic-5/ARA55 are required for nuclear matrix targeting and glucocorticoid receptor binding and coactivation.
TL;DR: Mapping studies of Hic‐5/ARA55 functional domains are reported and it is established that LIM3 and LIM4 are necessary for maximal effects on GR transactivation, however, results from yeast two‐hybrid assays demonstrated that these two LIM domains together, while necessary, are not sufficient to interact with the tau2 transactivation domain of GR.
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Interaction of the τ2 Transcriptional Activation Domain of Glucocorticoid Receptor with a Novel Steroid Receptor Coactivator, Hic-5, Which Localizes to Both Focal Adhesions and the Nuclear Matrix
TL;DR: It is proposed that Hic-5 might transmit signals that emanate at cell attachment sites and regulate transcription factors, such as steroid receptors,such as steroid receptor-mediated transcriptional activation.
Hormone-independent Transcriptional Activation and Coactivator Binding by Novel Orphan Nuclear Receptor ERR3
TL;DR: A novel orphan receptor, estrogen receptor-related protein 3 (ERR3), was identified by yeast two-hybrid screening, using the transcriptional coactivator glucocorticoid receptor interacting protein 1 (GRIP1) as bait, suggesting a unique role for ERR3 in development.