18 Papers
112 Citations
Lan Wei is an academic researcher from Australian National University. The author has contributed to research in topics: Ryanodine receptor & Calsequestrin. The author has an hindex of 14, co-authored 18 publications. Previous affiliations of Lan Wei include University of Rochester Medical Center & University of Rochester.
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Papers
Unique isoform-specific properties of calsequestrin in the heart and skeletal muscle
TL;DR: It is speculated that CSQ2 facilitates high rates of Ca(2+) release through RyR2 during systole, while CSQ1 curtails RyR1 opening in response to a single action potential to maintain Ca( 2+) and allow repeated Ca(1+) release and graded activation with increased stimulation frequency.
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Ca 2+ signaling in striated muscle: the elusive roles of triadin, junctin, and calsequestrin
TL;DR: The review of molecular interactions between calsequestrin, triadin, junctin and the ryanodine receptor in the lumen of the sarcoplasmic reticulum finds that cal sequestrin plays a different role in the heart and skeletal muscle, enhancing Ca2+ release in theHeart, but depressing Ca2- release in skeletal muscle.
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Junctin and triadin each activate skeletal ryanodine receptors but junctin alone mediates functional interactions with calsequestrin
TL;DR: It is shown that purified skeletal ryanodine receptors are similarly activated by purified triadin or purified junctin added to their luminal side, although a lack of competition indicated that the proteins act at independent sites.
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The conformation of calsequestrin determines its ability to regulate skeletal ryanodine receptors.
TL;DR: This work investigated the hypothesis that prolonged exposure to low luminal Ca2+ causes conformational changes in calsequestrin and deregulation of ryanodine receptors, allowing channel activity to increase.
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Mitochondrial superoxide flashes: From discovery to new controversies
Lan Wei,Robert T. Dirksen +1 more
TL;DR: This work has shown that reactive oxygen species generated during normal physiological processes are highly reactive with cellular lipids, DNA, and proteins, and both species need to be targeted for further investigation.