Lan V. Zhang

TL;DR: Because digenic interactions are common in yeast, similar networks may underlie the complex genetics associated with inherited phenotypes in other organisms.

TL;DR: This work investigated how hubs might contribute to robustness and other cellular properties for protein–protein interactions dynamically regulated both in time and in space, and uncovered two types of hub: ‘party’ hubs, which interact with most of their partners simultaneously, and ‘date’ Hubs, which bind their different partners at different times or locations.

TL;DR: A large fraction of the Caenorhabditis elegans interactome network is mapped, starting with a subset of metazoan-specific proteins, and more than 4000 interactions were identified from high-throughput, yeast two-hybrid screens.

TL;DR: Experimental evidence demonstrated the reliability of the predicted pairs of SSL genes in Saccharomyces cerevisiae by using probabilistic decision trees to integrate multiple types of data, including localization, mRNA expression, physical interaction, protein function, and characteristics of network topology.