6 Papers
83 Citations
Lan Qin is an academic researcher from University of Southern California. The author has contributed to research in topics: Hepatic stellate cell & Matrix metalloproteinase. The author has an hindex of 5, co-authored 5 publications.
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Papers
Epithelial to Mesenchymal Transition in Human Skin Wound Healing Is Induced by Tumor Necrosis Factor-α through Bone Morphogenic Protein-2
Chunli Yan,Wesley A. Grimm,Warren L. Garner,Lan Qin,Taryn E. Travis,Neiman Tan,Yuan-Ping Han +6 more
TL;DR: It is proposed that the mesenchymal induction in wound healing is motivated by TNF-alpha, in part, through induction of BMP, as revealed in both acute and fibrotic cutaneous wound healing of human skin.
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Stearoyl-CoA Desaturase Promotes Liver Fibrosis and Tumor Development in Mice via a Wnt Positive-Signaling Loop by Stabilization of Low-Density Lipoprotein-Receptor-Related Proteins 5 and 6
Keane K. Y. Lai,Soo-Mi Kweon,Feng Chi,Edward Hwang,Yasuaki Kabe,Reiichi Higashiyama,Lan Qin,Rui Yan,Raymond Wu,Keith Lai,Naoaki Fujii,Samuel W. French,Samuel W. French,Jun Xu,Jian Ying Wang,Ramachandran Murali,Ramachandran Murali,Lopa Mishra,Ju Seog Lee,James M. Ntambi,Hidekazu Tsukamoto,Hidekazu Tsukamoto +21 more
TL;DR: In rodent HSCs and TICs, SCD expression was found to be regulated by Wnt-β-catenin signaling, and MUFAs produced by SCD provided a forward loop to amplify Wnt signaling via stabilization of Lrp5 and LRp6 mRNAs, contributing to liver fibrosis and tumor growth.
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A Matrix Metalloproteinase-9 Activation Cascade by Hepatic Stellate Cells in Trans-differentiation in the Three-dimensional Extracellular Matrix
TL;DR: IL-1-induced trans-differentiation of HSCs in three-dimensional extracellular matrix is facilitated by an MMP activation cascade (MMP-14 > MMP-13 > M MP-9) and a positive feedback loop of Mmp-9 > MMM-13, suggesting their critical roles in liver injury and repair.
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Epigenetic Repression of Matrix Metalloproteinases in Myofibroblastic Hepatic Stellate Cells through Histone Deacetylases 4: Implication in Tissue Fibrosis
Lan Qin,Yuan-Ping Han +1 more
TL;DR: These findings suggest that a histone deacetylase-4-dependent mechanism underlies the epigenetic silencing of MMP genes during tissue fibrogenesis.
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Cathepsin H-Mediated Degradation of HDAC4 for Matrix Metalloproteinase Expression in Hepatic Stellate Cells: Implications of Epigenetic Suppression of Matrix Metalloproteinases in Fibrosis through Stabilization of Class IIa Histone Deacetylases.
Zemin Yang,Yu Liu,Lan Qin,Pengfei Wu,Zanxian Xia,Mei Luo,Yilan Zeng,Hidekazu Tsukamoto,Zongyun Ju,Danmei Su,Han Kang,Zhixiong Xiao,Sujun Zheng,Zhongping Duan,Richard Hu,Qiang Wang,Stephen J. Pandol,Yuan-Ping Han,Yuan-Ping Han +18 more
TL;DR: It is proposed that cysteine cathepsin-mediated degradation of class IIa HDACs plays a key role in the modulation of MMP expression/suppression and HSC functions in tissue injury and fibrosis.
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