Lan Ding
4 Papers
1 Citations
Lan Ding is an academic researcher. The author has contributed to research in topics: Chemistry & Microtubule. The author has an hindex of 1, co-authored 4 publications.
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Papers
Discovery of potent microtubule-destabilizing agents targeting for colchicine site by virtual screening, biological evaluation, and molecular dynamics simulation.
TL;DR: Zhang et al. as mentioned in this paper applied virtual screening methods, including pharmacophore model, molecular docking, and interaction molecular fingerprints similarity, to discover novel microtubule-destabilizing agents from database with 324,474 compounds.
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Wangzaozin A, a potent novel microtubule stabilizer, targets both the taxane and laulimalide sites on β-tubulin through molecular dynamics simulations.
TL;DR: Wangzaozin A, an ent-kaurene diterpenoid isolated from Isodon racemosa (Hemsl) Hara, promotes the polymerization of intracellular microtubules as well as purified tubulin, which is similar to other known microtubule stabilizers as discussed by the authors .
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Plagranline A, a Novel β-carboline and the First Alkaloid Isolated from Platycodon grandiflorus
TL;DR: In this paper , a β-carboline and a known alkaloid were isolated from the roots of Platycodon grandiflorus and their structure was elucidated using a combination of spectroscopic analyses and computational chemistry, including electronic circular dichroism and optical rotatory dispersion (ORD).