Lambratu Rahman
National Institutes of Health
5 Papers
22 Citations
Lambratu Rahman is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Thymidylate synthase & Exon. The author has an hindex of 5, co-authored 5 publications.
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Papers
Thymidylate synthase as an oncogene: a novel role for an essential DNA synthesis enzyme.
Lambratu Rahman,Donna Voeller,Monzur Rahman,Stan Lipkowitz,Carmen J. Allegra,J. Carl Barrett,Frederic J. Kaye,Maria Zajac-Kaye +7 more
TL;DR: It is shown that ectopic expression of catalytically active TS is sufficient to induce a transformed phenotype in mammalian cells as manifested by foci formation, anchorage independent growth, and tumor formation in nude mice and that overexpression of TS results in apoptotic cell death following serum removal.
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Alternative splicing of brain-specific PTB defines a tissue-specific isoform pattern that predicts distinct functional roles.
TL;DR: This work isolated a novel mRNA splice variant of nPTB from non-neuronal cells and identified a brain-specific transcript containing a novel, alternatively spliced, internal exon 10, which is associated with premature termination codon and results in the truncation of the open reading frame.
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EGFRvIII undergoes activation-dependent downregulation mediated by the Cbl proteins.
TL;DR: The EGfrvIII does not transform by escaping regulation by Cbl proteins and this activation-induced downregulation of the EGFRvIII has an important role in mediating the toxicity of anti-EGFRv III immunotoxins.
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Evolutionary conservation of a 2-kb intronic sequence flanking a tissue-specific alternative exon in the PTBP2 gene
TL;DR: The striking conservation of this large segment of flanking intronic sequence suggests an important role in tissue-specific splice site selection and may function in regulating the production of functional nPTB.
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Elevated levels of thymidylate synthase linked to neoplastic transformation of mammalian cells.
TL;DR: Thymidylate synthase, an enzyme that is essential for DNA synthesis and repair has been identified as an important biomarker for colorectal and other human cancers and may be an important factor for the control of cell cycle progression and for the development of therapeutic strategies and cancer prevention.