Lalitha Nayak

TL;DR: It is shown that endothelial KLF4 is an essential determinant of atherogenesis and thrombosis andMechanistically, it is demonstrated that KLF 4 differentially regulated pertinent endothelial targets via competition for the coactivator p300, and cogent evidence is provided implicated as essential in vivo regulators of vascular function in the adult animal.

TL;DR: Knowing the roles of neutrophils in thrombosis and inflammasome activation in the neutrophil may pave the road for novel anti-thrombotic agents in the future that do not affect hemostasis.

TL;DR: The most recent evidence on management of high-estrogen states in women at high-risk of thrombosis is reviewed, as well as emerging data on unique populations such as transgender women.

TL;DR: In this paper, the authors identify the Kruppel-like transcription factor 2 (KLF2) as a potent regulator of myeloid cell activation in vivo, and demonstrate that exposure to either hypoxia and/or bacterial products reduced KLF2 expression while inducing hypoxyia inducible factor 1α (HIF-1α), findings that were recapitulated in human septic patients.