Lai Wei
University of Hong Kong
25 Papers
17 Citations
Lai Wei is an academic researcher from University of Hong Kong. The author has contributed to research in topics: Biology & Medicine. The author has an hindex of 13, co-authored 17 publications. Previous affiliations of Lai Wei include Li Ka Shing Faculty of Medicine, University of Hong Kong.
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Papers
RNA N6-methyladenosine methyltransferase-like 3 promotes liver cancer progression through YTHDF2-dependent posttranscriptional silencing of SOCS2
Mengnuo Chen,Lai Wei,Cheuk-Ting Law,Felice Ho-Ching Tsang,Jialing Shen,Carol Lai-Hung Cheng,Long-Hin Tsang,Daniel W.H. Ho,David Kung-Chun Chiu,Joyce Man-Fong Lee,Carmen Chak-Lui Wong,Irene Oi-Lin Ng,Chun-Ming Wong +12 more
TL;DR: Methyltransferase‐like 3 (METTL3), a major RNA N6‐adenosine methyltransferase, was significantly up‐regulated in human hepatocellular carcinoma (HCC) and multiple solid tumors and suggest an important mechanism of epigenetic alteration in liver carcinogenesis.
1.2K
Genome-wide CRISPR/Cas9 library screening identified PHGDH as a critical driver for Sorafenib resistance in HCC
Lai Wei,Lai Wei,Derek Lee,Derek Lee,Cheuk-Ting Law,Cheuk-Ting Law,Misty Shuo Zhang,Misty Shuo Zhang,Jialing Shen,Jialing Shen,Don Wai-Ching Chin,Don Wai-Ching Chin,Allen Zhang,Allen Zhang,Felice Ho-Ching Tsang,Felice Ho-Ching Tsang,Ceci Lok-Sze Wong,Ceci Lok-Sze Wong,Irene Oi-Lin Ng,Irene Oi-Lin Ng,Carmen Chak-Lui Wong,Carmen Chak-Lui Wong,Chun-Ming Wong,Chun-Ming Wong +23 more
TL;DR: It is shown that phosphoglycerate dehydrogenase, a key enzyme in the serine synthesis pathway, drives sorafenib resistance, which is a major clinical challenge to overcome TKI drug resistance in HCC.
Up-regulation of histone methyltransferase SETDB1 by multiple mechanisms in hepatocellular carcinoma promotes cancer metastasis.
Chun-Ming Wong,Lai Wei,Cheuk-Ting Law,Daniel W.H. Ho,Felice Ho-Ching Tsang,Sandy Leung-Kuen Au,Karen Man-Fong Sze,Joyce Man-Fong Lee,Carmen Chak-Lui Wong,Irene Oi-Lin Ng +9 more
TL;DR: SETDB1 is an oncogene that is frequently up‐regulated in human HCCs; the multiplicity of SETDB1 activating mechanisms at the chromosomal, transcriptional, and posttranscriptional levels together facilitates SETDB said to be essential for HCC metastatic progression.
156
Histone methyltransferase G9a promotes liver cancer development by epigenetic silencing of tumor suppressor gene RARRES3
Lai Wei,David Kung-Chun Chiu,Felice Ho-Ching Tsang,Felice Ho-Ching Tsang,Cheuk-Ting Law,Cheuk-Ting Law,Carol Lai-Hung Cheng,Carol Lai-Hung Cheng,Sandy Leung-Kuen Au,Sandy Leung-Kuen Au,Joyce Man-Fong Lee,Joyce Man-Fong Lee,Carmen Chak-Lui Wong,Carmen Chak-Lui Wong,Irene Oi-Lin Ng,Irene Oi-Lin Ng,Chun-Ming Wong,Chun-Ming Wong +17 more
TL;DR: This study shows a frequent deregulation of miR-1/G9a/RARRES3 axis in liver carcinogenesis, highlighting the pathological significance of G9a and its therapeutic potential in HCC treatment.
141
Long non-coding RNA HOTTIP is frequently up-regulated in hepatocellular carcinoma and is targeted by tumour suppressive miR-125b
Felice Ho-Ching Tsang,Sandy Leung-Kuen Au,Lai Wei,Dorothy Ngo-Yin Fan,Joyce Man-Fong Lee,Carmen Chak-Lui Wong,Irene Oi-Lin Ng,Chun-Ming Wong +7 more
TL;DR: This study aimed to investigate the expression and functional implications of lncRNAs in human HCC and suggested the role of long non‐coding RNAs (lncRNA) in human carcinogenesis.
140