LaDeana W. Hillier
University of Washington
144 Papers
2K Citations
LaDeana W. Hillier is an academic researcher from University of Washington. The author has contributed to research in topics: Genome & Biology. The author has an hindex of 79, co-authored 131 publications. Previous affiliations of LaDeana W. Hillier include Children's Hospital Oakland Research Institute & Wellcome Trust Sanger Institute.
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Papers
The Million Mutation Project: A new approach to genetics in Caenorhabditis elegans
Owen Thompson,Mark L. Edgley,Pnina Strasbourger,Stephane Flibotte,Brent Ewing,Ryan Adair,Vinci Au,Iasha Chaudhry,Lisa Fernando,Harald Hutter,Armelle Kieffer,Joanne Lau,Norris Lee,Angela Miller,Greta Raymant,Bin Shen,Jay Shendure,Jon Taylor,Emily H. Turner,LaDeana W. Hillier,Donald G. Moerman,Robert H. Waterston +21 more
TL;DR: A nonsense suppressor is revealed as well as strains with higher levels of indels that harbor mutations in DNA repair genes and strains with abundant males associated with him mutations, providing an unprecedented genetic resource for this multicellular organism.
High Throughput Fingerprint Analysis of Large-Insert Clones
Marco A. Marra,Tamara A. Kucaba,Nicole Dietrich,Eric D. Green,B. Brownstein,Richard K. Wilson,Ken M. McDonald,LaDeana W. Hillier,John Douglas Mcpherson,Robert H. Waterston +9 more
TL;DR: It is shown that the fingerprints are of sufficient quality to permit the construction of megabase-size contigs in defined regions of the human genome and it is anticipated that the high throughput and precision characteristic of the fingerprinting method will make it of general utility.
Long-read sequence assembly of the gorilla genome.
David Gordon,John Huddleston,Mark Chaisson,Christopher M. Hill,Zev N. Kronenberg,Katherine M. Munson,Maika Malig,Archana Raja,Ian T. Fiddes,LaDeana W. Hillier,Christopher Dunn,Carl Baker,Joel Armstrong,Mark Diekhans,Benedict Paten,Jay Shendure,Richard K. Wilson,David Haussler,Chen-Shan Chin,Evan E. Eichler +19 more
TL;DR: The genome assembly that results from using the long-read data provides a more complete picture of gene content, structural variation, and repeat biology, improving population genetic and evolutionary inferences.
386
A survey of expressed genes in Caenorhabditis elegans.
Robert H. Waterston,Charles E. Martin,M. Craxton,C. Huynh,Alan Coulson,LaDeana W. Hillier,Richard Durbin,Philip Green,Ratna Shownkeen,Nicolette D. Halloran,Mark M. Metzstein,T. Hawkins,Richard K. Wilson,Mary Berks,Zijin Du,K. Thomas,Jean Thierry-Mieg,John Sulston +17 more
TL;DR: The result is the identification of about 1,200 of the estimated 15,000 genes of C. elegans, providing a more accurate estimate of the total number of genes in the organism than has hitherto been available.
377
The nucleotide sequence of Saccharomyces cerevisiae chromosome VII.
Mark Johnston,LaDeana W. Hillier,Linda Riles,K. Albermann,Brigitte André,W. Ansorge,V. Benes,M. Bruckner,Hajo Delius,E. Dubois,A. Düsterhöft,Kd. Entian,M. Floeth,André Goffeau,U. Hebling,K. Heumann,D. Heussneitzel,H. Hilbert,F. Hilger,K. Kleine,Peter Kötter,Edward J. Louis,F. Messenguy,Hw. Mewes,T. Miosga,D. Mostl,S. Mullerauer,U. Nentwich,B. Obermaier,E. Piravandi,Tm. Pohl,Daniel Portetelle,Bénédicte Purnelle,S. Rechmann,Michael A. Rieger,M. Rinke,Matthias Rose,M. Scharfe,B. Scherens,P. Scholler,Christian Schwager,S. Schwarz,Ap. Underwood,La. Urrestarazu,Micheline Vandenbol,P. Verhasselt,F. Vierendeels,M. Voet,G. Volckaert,H. Voss,R. Wambutt,E. Wedler,H. Wedler,Fk. Zimmermann,A. Zollner,J. Hani,Jd. Hoheisel +56 more
TL;DR: No correlation was found between G+C content and gene density along the chromosome, and their variations are random, so accurate verification procedures demonstrate that there are less than two errors per 10,000 base pairs in the published sequence.