L. Trachsel
Max Planck Society
18 Papers
241 Citations
L. Trachsel is an academic researcher from Max Planck Society. The author has contributed to research in topics: Slow-wave sleep & Sleep in non-human animals. The author has an hindex of 12, co-authored 18 publications.
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Papers
DHEA administration increases rapid eye movement sleep and EEG power in the sigma frequency range.
TL;DR: DHEA administration has a mixed GABAA-agonistic/antagonistic effect, exerted either directly or through DHEA-induced changes in steroid metabolism, which suggests the potential clinical usefulness of D HEA in age-related dementia.
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Acute cortisol administration promotes sleep intensity in man.
TL;DR: It appears likely that a negative feedback inhibition of endogenous CRH was the key mechanism mediating the observed results, and cortisol-induced effects on sleep intensity and sleep-associated GH secretion appeared to be driven by different mechanisms.
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The 5-HT1A agonist ipsapirone enhances EEG slow wave activity in human sleep and produces a power spectrum similar to 5-HT2 blockade
TL;DR: It is proposed that the spectral data following the lower ipsapirone dose reflect a net decrease of neuronal activity at 5-HT2 receptors, mediated through stimulation of somatodendritic autoreceptors in the raphe nuclei (presynaptic) and/orThrough stimulation of postsynaptic5-HT1A receptors colocalized with 5- HT2 receptors.
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Sleep and mammalian hibernation: homologous adaptations and homologous processes?
TL;DR: Although the slight down-regulation of Tb and metabolism that accompanies the transition from wakefulness to NREM sleep may have served as a pre adaptation for the evolution of hibernation among the mammals, increasing consideration must be given to the possibility that hibernation represents an arousal state distinct from any known normothermic arousal state.
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Endotoxin enhances EEG alpha and beta power in human sleep
TL;DR: It is concluded that in humans the primary host response induced by endotoxin initially suppresses REM sleep and increases stage 2 NREM sleep, but does not affect slow-wave sleep (SWS, stages 3 and 4), and no clear modification of sleep EEG delta activity could be observed after endotoxin injection.
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