L Shepherd
Northern General Hospital
10 Papers
382 Citations
L Shepherd is an academic researcher from Northern General Hospital. The author has contributed to research in topics: Restenosis & Neointima. The author has an hindex of 8, co-authored 10 publications.
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Papers
Apoptosis and Cell Proliferation After Porcine Coronary Angioplasty
Nadim Malik,Sheila E. Francis,Cathy M. Holt,Julian Gunn,Graham L. Thomas,L Shepherd,Janet Chamberlain,Chris Newman,David C. Cumberland,David C. Crossman +9 more
TL;DR: The results suggest that the profile of apoptosis and proliferation after PTCA is regional and cell specific, and attempts to modulate either of these events for therapeutic benefit requires recognition of these differences.
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The Effect of Oligonucleotides to c-myb on Vascular Smooth Muscle Cell Proliferation and Neointima Formation After Porcine Coronary Angioplasty
Julian Gunn,Cathy M. Holt,Sheila E. Francis,L Shepherd,Malcolm Grohmann,Chris Newman,David C. Crossman,David C. Cumberland +7 more
TL;DR: In this article, the authors investigated the specificity of action of antisense oligodeoxynucleotides (AS-ODN-c-myb) in vitro and assessed its effect, when delivered locally, on neointima formation after percutaneous transluminal coronary angioplasty (PTCA) in porcine coronary arteries.
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Intravascular stents: a new technique for tissue processing for histology, immunohistochemistry, and transmission electron microscopy
Nadim Malik,Julian Gunn,Cathy M. Holt,L Shepherd,Sheila E. Francis,Chris Newman,David C. Crossman,David C. Cumberland +7 more
TL;DR: This study identified the optimal methods for embedding, sawing, grinding, and slide mounting of stented arteries to achieve 5 μm sections with an intact tissue metal interface, excellent surface qualities, histological and immunohistochemical staining properties, and suitability for TEM examination.
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•Journal Article
Phosphorylcholine-coated stents in porcine coronary arteries: in vivo assessment of biocompatibility.
TL;DR: The divYsio stents, with or without PC coating, performed equally well in terms of acute patency, 28-day QCA and morphometry, and the PC coating allows a stent to endothelialize normally and is not associated with specific histological changes.
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Effects of radiographic contrast media on proliferation and apoptosis of human vascular endothelial cells.
TL;DR: Saturated mannitol and all tested RCM, with the exception of iotrolan, (diatrizoate > ioxaglate > iopromide) reduced proliferation and increased apoptosis of HUVECs and seem to depend on osmolality as well as the chemical structure of these agents.
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