L. Raffield
24 Papers
L. Raffield is an academic researcher. The author has contributed to research in topics: Internal medicine & Medicine. The author has co-authored 2 publications.
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Papers
Mosaic chromosomal alterations in blood across ancestries using whole-genome sequencing
Yasminka A. Jakubek,Ying Zhou,Adrienne M. Stilp,Jason Bacon,Justin Wong,Zuhal Ozcan,Donna K. Arnett,Kathleen C. Barnes,Joshua C. Bis,Eric Boerwinkle,Jennifer A. Brody,April P Carson,Daniel I. Chasman,Jiawen Chen,Michael H. Cho,Matthew P. Conomos,Nancy Cox,Margaret F Doyle,Myriam Fornage,Xiuqing Guo,S. Kardia,Joshua P. Lewis,Ruth J. F. Loos,X. Ma,Mitchell J. Machiela,T. Mack,Rasika A. Mathias,Braxton D. Mitchell,Josyf C. Mychaleckyj,Kari North,Nathan James Pankratz,Patricia A. Peyser,Michael Preuss,B. Psaty,L. Raffield,Ramachandran S. Vasan,Susan Redline,Stephen S. Rich,Jerome I. Rotter,Edwin K. Silverman,Jennifer A. Smith,Aaron P Smith,Margaret A. Taub,Kent D. Taylor,Jeong Yun,Yun Li,Pinkal Desai,Alexander G. Bick,Alexander P. Reiner,Paul Scheet,Paul L. Auer +50 more
TL;DR: Three loci associated with loss of chromosome X, associations between autosomal mCAs and rare variants in DCPS, ADM17, PPP1R16B and TET2 and ancestry-specific variants in ATM and MPL with mCAs in cis are reported.
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Association Between Whole Blood-Derived Mitochondrial DNA Copy Number, Low-Density Lipoprotein Cholesterol, and Cardiovascular Disease Risk.
Xue Liu,Xianbang Sun,Yuankai Zhang,Wenqing Jiang,Meng Lai,Kerri L. Wiggins,L. Raffield,Lawrence F. Bielak,Wei Zhao,Achilleas N. Pitsillides,Jeffrey Haessler,Yinan Zheng,Thomas W. Blackwell,Jie Yao,Xiuqing Guo,Yong Qian,Bharat Thyagarajan,Nathan James Pankratz,Stephen S. Rich,Kent D Taylor,Patricia A. Peyser,Susan R. Heckbert,Sudha Seshadri,Eric Boerwinkle,Megan L. Grove,Nicholas B Larson,Jennifer A. Smith,Ramachandran S. Vasan,Annette L. Fitzpatrick,Myriam Fornage,Jun Ding,April P Carson,Gonçalo R. Abecasis,José E Dupuis,Alexander P. Reiner,Charles Kooperberg,Lifang Hou,B. Psaty,James G. Wilson,Daniel Levy,Jerome I. Rotter,Joshua B. Bis,Claudia L. Satizabal,Dan E. Arking,Chunyu Liu +44 more
TL;DR: High low‐density lipoprotein cholesterol may underlie the complex relationships between mtDNA CN and vascular atherosclerosis, as well as obesity, diabetes, and hypertension.
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Type 2 Diabetes Modifies the Association of CAD Genomic Risk Variants With Subclinical Atherosclerosis
Natalie R Hasbani,Kenneth E Westerman,Soo Heon Kwak,Han Chen,Xihao Li,Daniel Di Corpo,Jennifer Wessel,Joshua B. Bis,Chloé Sarnowski,Peitao Wu,Lawrence F. Bielak,Xiuqing Guo,Nancy L. Heard-Costa,Gregory Kinney,Michael C. Mahaney,May E. Montasser,Nicholette D. Palmer,L. Raffield,James G. Terry,Lisa R. Yanek,Jessica Bon,Donald W. Bowden,Jennifer A. Brody,Ravindranath Duggirala,David R Jacobs,Rita Kalyani,Leslie A. Lange,Braxton D. Mitchell,Jennifer A. Smith,Kent D. Taylor,April P Carson,Joanne E. Curran,Myriam Fornage,Barry I. Freedman,Stacey B. Gabriel,R. A. Gibbs,Namrata Gupta,S. Kardia,Brian G. Kral,Zeineen Momin,Anne B Newman,W. S. Post,Karine A. Viaud-Martinez,Kendra A. Young,Lewis C Becker,Alain Bertoni,John Blangero,J. J. Carr,Katherine A. Pratte,B. Psaty,Stephen S. Rich,Joseph C. Wu,Rajeev Malhotra,Patricia A. Peyser,Alanna C. Morrison,Ramachandran S. Vasan,Xihong Lin,Jerome I. Rotter,James B Meigs,Alisa K Manning,Paul S. de Vries +60 more
TL;DR: T2D is highlighted as an important modifier of rare variant associations in CAD loci with CAC, and ATP1B1 and ARVCF also had significantly different associations for CAC in T2D cases versus controls.
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A statistical framework for powerful multi-trait rare variant analysis in large-scale whole-genome sequencing studies
Xihao Li,Han Chen,M. Selvaraj,Eric Van Buren,Hufeng Zhou,Yuxuan Wang,Ryan Sun,Zachary R. McCaw,Zhi Yu,Donna K. Arnett,Joshua B. Bis,John Blangero,Eric Boerwinkle,Donald W. Bowden,Jennifer A. Brody,Brian E. Cade,April P Carson,Jenna C. Carlson,Nathalie Chami,Yii-DerIda Chen,Joanne E. Curran,Paul S. de Vries,Myriam Fornage,Nora Franceschini,Barry I. Freedman,Charles C. Gu,Nancy L. Heard-Costa,Jiang He,Lifang Hou,Yi Jen Hung,Marguerite R. Irvin,Robert C. Kaplan,S. Kardia,Tanika Kelly,Iain R. Konigsberg,Charles Kooperberg,Brian G. Kral,Changwei Li,R. Loos,Michael C. Mahaney,Lisa W. Martin,Rasika A. Mathias,Ryan L. Minster,Braxton D. Mitchell,May E. Montasser,Alanna C. Morrison,Nicholette D. Palmer,Patricia A. Peyser,B. Psaty,L. Raffield,Susan Redline,Alexander P. Reiner,Stephen S. Rich,Colleen M. Sitlani,Jennifer A. Smith,Kent D. Taylor,Hemant K. Tiwari,Ramachandran S. Vasan,Zhe Wang,Lisa R. Yanek,Bing Yu,Ken Rice,Jerome I. Rotter,Gina M. Peloso,Pradeep Natarajan,Zilin Li,Zhonghua Liu,Xihong Lin +67 more
TL;DR: This work proposes MultiSTAAR, a statistical framework and computationally-scalable analytical pipeline for functionally-informed multi-trait rare variant analysis in large-scale WGS studies, and applies it to jointly analyze three lipid traits in 61,861 multi-ethnic samples from the Trans-Omics for Precision Medicine Program.
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Branched chain amino acids harbor distinct and often opposing effects on health and disease
Christy L. Avery,Annie Green Howard,Harold H Lee,Carolina Downie,Moa P Lee,Sarah H Koenigsberg,Anna F Ballou,Michael Preuss,L. Raffield,Rina A. Yarosh,Kari E North,Penny Gordon-Larsen,Mariaelisa Graff +12 more
TL;DR: This study uses Mendelian randomization to investigate the causal effects of branched chain amino acids (BCAAs) on various health outcomes, revealing distinct and often opposing effects for each BCAA, contradicting previous observational studies and highlighting the need for causal inference approaches in 'omics research.
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